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Inv phenotypes and quantitative gamma globulin determinations in leprosy patients and control populations from India and Thailand

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Summary

Two problems were examined: 1. Is there an association between prevalence and clinical course of leprosy and the Inv(1) polymorphism? 2. Do the Inv(1) types influence the amount of gamma globulin present in the serum?

Material: 961 Indians (302 with lepromatous, 284 with nonlepromatous leprosy; 375 controls) from 5 different caste groups, districts of Bankura and Purulia, West Bengal; 494 leprosy patients from Thailand (240 with lepromatous, 254 with nonlepromatous leprosy); 988 controls; this control group was examined only for Inv type, not for gamma globulins.

Results: 1. There seems to be no association between leprosy and Inv type. 2. No association between Inv type and gamma globulin content of the serum was found. 3. The phenotype frequencies in the Inv system are within the range known for other Indian and Asian populations.

Zusammenfassung

Zwei Probleme wurden untersucht: 1. Besteht eine Beziehung zwischen der Häufigkeit und dem klinischen Verlauf der Lepra und dem Inv(1)-Polymorphismus? 2. Beeinflussen die Inv(1)-Typen die Gammaglobulinmenge im Serum?

Material: 961 Inder (302 mit lepromatöser, 284 mit nichtlepromatöser Lepra; 375 Kontrollen) aus 5 verschiedenen Kasten und aus den Distrikten Bankura und Purulia, West-Bengalen, 494 Leprapatienten aus Thailand (240 mit lepromatöser, 254 mit nichtlepromatöser Lepra); 988 Kontrollen. Diese Kontrollgruppe wurde nur auf dem Inv-Typ, nicht auf Gammaglobuline hin untersucht.

Ergebnisse: 1. Es besteht offenbar keine Beziehung zwischen Lepra und Inv-Typ. 2. Es konnte keine Beziehung zwischen dem Inv-Typ und dem Gammaglobulingehalt des Serums aufgefunden werden. 3. Die Phänotyp-Häufigkeiten im Inv-System bewegen sich im Rahmen dessen, was für andere indische und asiatische Populationen bekannt ist.

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References

  • Chopra, V. P.: Studies on serum groups in the Kumaon region, India. Humangenetik 10, 35–43 (1970).

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Author notes

  1. G. Flatz

    Present address: Universitäts-Kinderklinik, Bonn

Authors and Affiliations

  1. Institut für Anthropologie und Humangenetik der Universität Heidelberg, Heidelberg, Germany

    F. Vogel & J. Krüger

  2. Department of Anthropology, Andhra University, Waltair, India

    M. R. Chakravartti

  3. Human Genetics Laboratory, Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

    G. Flatz

  4. Institut für Anthropologie und Humangenetik der Universität Tübingen, Tubingen, Germany

    H. Ritter

Authors
  1. F. Vogel
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  2. J. Krüger
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  3. M. R. Chakravartti
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  4. G. Flatz
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  5. H. Ritter
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Additional information

This study was supported by the Stiftung Volkswagenwerk and the Deutsche Forschungsgemeinschaft.

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Vogel, F., Krüger, J., Chakravartti, M.R. et al. Inv phenotypes and quantitative gamma globulin determinations in leprosy patients and control populations from India and Thailand. Hum Genet 12, 35–41 (1971). https://doi.org/10.1007/BF00291030

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  • DOI: https://doi.org/10.1007/BF00291030

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