Abstract
Meiotic chromosome segregation must occur with high fidelity in order to prevent the generation of aneuploid cells. We have previously described the identification and genetic characterization of a yeast mutant with defects in meiotic sister-chromatid segregation. We attributed the phenotype in this mutant to a dominant allele, which we referred to as SID1-1. These mutants appeared to exhibit high levels of nondisjunction and precocious separation of sister-chromatids of chromosome III, as well as precocious separation of sister chromatids of chromosome VIII and a univalent artificial chromosome. We show here that the unusual meiotic behavior of chromosome III in these strains is due to the presence of a ring III chromosome, rather than a mutant gene. Additional experiments demonstrate that a ring III/rod III pair alters the meiotic segregation of a univalent artificial chromosome.
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Communicated by B. J. Kilbey
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Flatters, M., Maxfield, R. & Dawson, D. The eects of a ring chromosome on the meiotic segregation of other chromosomes in Saccharomyces cerevisiae . Molec. Gen. Genet. 249, 309–316 (1995). https://doi.org/10.1007/BF00290532
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DOI: https://doi.org/10.1007/BF00290532