Summary
The karyotype of leukemic cells of 78 acute leukemia patients (37 ANLL, 34ALL, and 7 of unknown type) was studied by means of G-banding. Chromsomal abnormalities were found in 50 patients (72%). Chromosomes 8, 21, 5, 7, 11, and 19 were preferentially involeved in the abnormalities, both in ANLL and in ALL. A high incidence of the characteristic rearrangement t(8,21) was noted in AML: (in 6 of 22 AML patients). An identical reciprocal translocation—t(4;11)—was seen in 4 out of 34 ALL patients.
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Berghe, H. van den, Börstrem, G. H., Brandt, L., Catovsky, D., Chapelle, A. de la, Golomb, H., Hossfeld, D. K., Lawler, S., Lindsten, J., Louwagie, A., Mitelman, F., Reeves, B. R., Rowley, J. D., Sandberg, A. A., Teerenhovi, L., Vuopio, P.: Chromosomes in acute non-lymphocytic leukemia. Br. J. Haematol. 39, 311–316 (1978)
Berghe, H. van den, David, G., Broekhaert-Van Orshoven, A., Louwagie, A., Verwilghen, R., Casteels-Van Daele, M., Eggermont, E., Eekels, R.: A new chromosome anomaly in acute lymphoblastic leukemia (ALL). Hum. Genet. 46, 173–180 (1979)
Cimino, M. C., Rowley, J. D., Kinnealey, A., Variakojis, D., Golomb, H. M.: Banding studies of chromosome abnormalities in patients with acute lymphocytic leukemia. Cancer Res. 39, 227–238 (1979)
Fukuhara, S.: Significance of 14q translocation in non-Hodgkin lymphomas. Virchows Arch. [Cell Pathol.] 29, 99–106 (1978)
Golomb, H.: Clinical implications of chromosome abnormalities in acute non-lymphocytic leukemia: current status. Virchows Arch. [Cell Pathol.] 29, 93–97 (1978)
Golomb, H. M., Vardiman, J., Rowley, J. D.: Acute non-lymphocytic leukemia in adults: correlations with Q-banded chromosomes. Blood 48, 9–21 (1976)
Heenen, W. K.: HeLa cells and their possible contamination of other all lines: Karyotype studies. Hereditas 82, 217–248 (1976)
Louwagie, A. C., Broeckhaart-Van Orshoven, A., van den Berghe, H.: acute promyelocytic leukemia: Incidence of leukopenia, karyotypic anomaly: t(15q+;17q-) and disseminated intravascular coagulation. Abstr. XVII Congr. Int. Soc. Hematol., Paris, 696 (1978)
Mitelman, F., Levan, G.: Clustering of aberration to specific chromosomes in human neoplasms. III. Incidence and geographic distribution of chromosome aberrations in 856 cases. Hereditas 89, 207–232 (1978)
Oshimura, M., Freeman, A. J., Sandberg, A. A.: Chromosomes and causation of human cancer and leukemia. XVII. Banding studies in acute lymphoblastic leukemia (ALL). Cancer 40, 1161–1172 (1977)
Oshimura, M., Hayata, I., Kakati, S., Sandberg, A. A.: Chromosomes and causation of human cancer and leukemia. XVII. Banding studies in acute myeloblastic leukemia (AML). Cancer 38, 748–761 (1976)
Paris Conference (1971): Standardization in human cytogenetics. Birth defects: Original article series, VIII, 7, 1972. The National Foundation, New York
Prigogina, E. L., Fleischman, E. W., Volkova, M. A., Frenkel, M. A.: Chromosome abnormalities and clinical and morphologic manifestations of chronic myeloid leukemia. Hum. Genet. 41, 143–156 (1978)
Quinn, L. A., Woods, L. K., Merrick, S. B., Arabasz, N. M., Morre, G. E.: Cytogenetic analysis of twelve human malignant melanoma cell lines. J. Natl. Cancer Inst. 59, 301–307 (1977)
Reeves, B. R.: Cytogenetics of malignant lymphomas. Studies utilizing a Giemsa banding technique. Humangenetik 20, 231–250 (1973)
Rowley, J. D.: Identification of a translocation with quinacrine fluorescence in a patient with acute leukemia. Ann. Genet. 16, 109–112 (1973)
Rowley, J. D.: Chromosomes in leukemia and lymphoma. Semin. Hematol. 15, 301–318 (1978)
Rowley, J. D., Golomb, H. M., Vardiman, J.: Nonrandom chromosomal abnormalities in acute nonlymphocytic leukemia in patients treated for Hodgkin disease and non-Hodgkin lymphomas. Blood 50, 759–770 (1977a)
Rowley, J. D., Golomb, H. M., Dougherty, C.: 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukemia. Lancet 1977I, 549–550
Rowley, J. D., Potter, D.: Chromosomal banding pattern in acute nonlymphocytic leukemia. Blood 47, 705–722 (1976)
Sakurai, M., Oshimura, M., Kakati, S., Sandberg, A. A.: 8–21 translocation and missing sex chromosomes in acute leukemia. Lancet 1974II, 227–228
Sakurai, M., Sandberg, A. A.: Chromosomes and causation of human cancer and leukemia. XI. Correlation of karyotyes with clinical features of acute myeloblastic leukemia. Cancer 37, 285–299 (1976)
Sandberg, A. A., Ishihara, L. H., Kikuchi, J., Crosswhite, L. H.: Chromosomal differences among the acute leukemias. Ann. NY Acad. Sci. 17, 738–746 (1964)
Seabright, M.: A rapid banding technique for human chromosomes. Lancet 1971II, 971–972
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Prigogina, E.L., Fleischman, E.W., Puchkova, G.P. et al. Chromosomes in acute leukemia. Hum Genet 53, 5–16 (1979). https://doi.org/10.1007/BF00289443
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DOI: https://doi.org/10.1007/BF00289443