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Chromosomes in acute leukemia

Human Genetics volume 53, pages 5–16 (1979)Cite this article

Summary

The karyotype of leukemic cells of 78 acute leukemia patients (37 ANLL, 34ALL, and 7 of unknown type) was studied by means of G-banding. Chromsomal abnormalities were found in 50 patients (72%). Chromosomes 8, 21, 5, 7, 11, and 19 were preferentially involeved in the abnormalities, both in ANLL and in ALL. A high incidence of the characteristic rearrangement t(8,21) was noted in AML: (in 6 of 22 AML patients). An identical reciprocal translocation—t(4;11)—was seen in 4 out of 34 ALL patients.

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Affiliations

  1. Cencer Research Center, AMS USSR, Kashirskoye shosse, 6, 115478, Moscow, USSR

    E. L. Prigogina, E. W. Fleischman, G. P. Puchkova, O. E. Kulagina, S. A. Majakova, S. A. Balakirev, M. A. Frenkel, N. V. Khvatova & I. S. Peterson

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  1. E. L. Prigogina
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  2. E. W. Fleischman
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  3. G. P. Puchkova
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  4. O. E. Kulagina
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  5. S. A. Majakova
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  6. S. A. Balakirev
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  7. M. A. Frenkel
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  8. N. V. Khvatova
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  9. I. S. Peterson
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Prigogina, E.L., Fleischman, E.W., Puchkova, G.P. et al. Chromosomes in acute leukemia. Hum Genet 53, 5–16 (1979). https://doi.org/10.1007/BF00289443

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  • DOI: https://doi.org/10.1007/BF00289443

Keywords

  • Internal Medicine
  • Leukemia
  • Metabolic Disease
  • Leukemic Cell
  • Acute Leukemia