Abstract
A new high yield 123I radioiodination (97%), based on the Cu(I) assisted isotopic exchange in an ethanol water mixture, of 15(p-I-phenyl)-9 methyl pentadecanoic acid, a potential myocardial tracer, is proposed. The method allows a true kit preparation of radioiodinated phenyl fatty acids for a substrate concentration of ±10-6 moles. High specific activities (>0.1 mCi/μg) can be obtained when coupling the labelling method to HPLC purification with an overall radiochemical yield of 75%.
This is a preview of subscription content, log in via an institution to check access.
References
Foster NI, Heindel ND, Burns HD (1980) Aryl iodides from amines via triazene intermediates. Synthesis 572
Kulkarni PV, Parkey RW (1982a) A new radioiodination method utilizing organothallium intermediate: Radioiodination of phenyl pentadecanoic acid (PPA) for potential applications in myocardial imaging. J Nucl Med 23:105
Kulkarni PV, Parkey RW (1982b) Radioiodination of phenyl pentadecanoic acid via an organothallium intermediate. In: Fourth International Symposium on Radiopharmaceutical Chemistry. Jülich, FRG, August 23–27, 1982, p 49
Machulla HJ, Marsmann M, Dutschka K (1980a) Biochemical concept and synthesis of a radioiodinated phenyl fatty acid for in vivo metabolic studies of the myocardium. Eur J Nucl Med 5:171
Machulla HJ, Marsmann M, Dutschka K (1980b) Radiopharmaceuticals Synthesis of radioiodinated phenyl fatty acids for studying myocardial methabolism. J Radioanal Chem 56:253–261
Mertens J, Vanryckeghem W (1985a) Fast Kit Labelling: New future for pure 123I Labelled Radiopharmaceuticals. In: Abstracts European Nuclear Medicine Congress, London 1985, p 206
Mertens J, Vanryckeghem W, Carlsen L (1985b) Cu(I) supported isotopic exchange of arylbound iodide, new future for fast high yield labelling. In: Proceedings of the Second European Symposium on Radiopharmacy and Radiopharmaceuticals, Cambridge, March, 1985
Mertens J, Vanryckeghem W, Bossuyt A, Van den Winkel P, Van den Driessche R (1984) Fast low temperature ultrasonic synthesis and injection ready preparation of carrier free 17-I-123-heptadecanoic acid. J Lab Comp Radiopharm 21:843–856
Van der Wall EE, Westera G, den Hollander W (1981) Fatty acids clinical pharmacology. Myocardial scintigraphy with I-123-hexadecanoic acid and I-123-heptadecanoic acid. In: Cox PH (ed) Progress in Radiopharmacy, vol 2. Elsevier/North-Holland, New York, Oxford, pp 53–59
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mertens, J., Eersels, J. & Vanryckeghem, W. New high yield Cu(I) assisted 123I radioiodination of 15(p-I-phenyl)-9-methyl pentadecanoic acid, a potential myocardial tracer. Eur J Nucl Med 13, 159–160 (1987). https://doi.org/10.1007/BF00289030
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00289030