Skip to main content

Chromosomal localization of ARSB, the gene for human N-acetylgalactosamine-4-sulphatase


A deficiency of N-acetylgalactosamine-4-sulphatase (G4S, gene symbol ARSB), results in the accumulation of undegraded substrate and the lysosomal storage disorder, Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI). In situ hybridization using an 3H-labelled human G4S genomic DNA fragment to human metaphase chromosomes localized ARSB to chromosome 5q13–5q14. This location is consistent with, an refines, previous chromosomal assignments based on the expression of human G4S in somatic cell hybrids.

This is a preview of subscription content, access via your institution.


  • Callen DF, Hyland VJ, Baker EG, Fratini A, Simmers RN, Mulley JC, Sutherland GR (1988) Fine mapping of gene probes and anonymous DNA fragments to the long arm of chromosome 16. Genomics 2:144–153

    Google Scholar 

  • Dana S, Wasmuth JJ (1982) Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5. Mol Cell Biol 2: 1220–1228

    Google Scholar 

  • DeLuca C, Brown JA, Shows TB (1979) Lysosomal arylsulfatase deficiencies in humans: chromosome assignments for arylsulfatase A and B. Proc Natl Acad Sci USA 76:1957–1961

    Google Scholar 

  • Fidzianska E, Abramowicz T, Czartoryska B, Glogowska I, Gorska D, Rodo M (1984) Assignment of the gene for human arylsulfatase B, ARSB, to chromosome region 5p11-5qter. Cytogenet Cell Genet 38:150–151

    Google Scholar 

  • Fox MF, DuToit DL, Warnich L, Retief AE (1984) Regional localization of α-galactosidase (GLA) to Xpter-q22, hexosaminidase B (HEXB) to 5q13-qter, and arylsulfatase B (ARSB) to 5pter-q13. Cytogenet Cell Genet 38:45–49

    Google Scholar 

  • Gibson GJ, Saccone GTP, Brooks DA, Clements PR, Hopwood JJ (1987) Human N-acetylgalactosamine-4-sulphate sulphatase: purification, monoclonal antibody production and native and subunit Mr values. Biochem J 248:755–764

    Google Scholar 

  • Hellkuhl B, Grzeschik K-H (1978) Assignment of a gene for arylsulfatase B to human chromosome 5 using human-mouse somatic cell hybrids. (4th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 22:203–206

    Google Scholar 

  • Hopwood JJ, Elliott H, Muller VJ, Saccone GTP (1986) Diagnosis of Maroteaux-Lamy syndrome by the use of radiolabelled oligosaccharides as substrates for the determination of arylsulphatase B activity. Biochem J 234:507–514

    Google Scholar 

  • Maniatis T, Fritsch EF, Sambrook J (eds) (1982) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

    Google Scholar 

  • McKusick VA, Neufeld EF (1983) The mucopolysaccharide storage diseases. In: Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease. McGraw-Hill, New York, pp 751–777

    Google Scholar 

  • Robertson DA, Callen DF, Baker EG, Morris CP, Hopwood JJ (1988) Chromosomal localization of the gene for human glucosamine-6-sulphatase to 12q14. Hum Genet 79:175–178

    Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Litjens, T., Baker, E.G., Beckmann, K.R. et al. Chromosomal localization of ARSB, the gene for human N-acetylgalactosamine-4-sulphatase. Hum Genet 82, 67–68 (1989).

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI:


  • Internal Medicine
  • Metabolic Disease
  • Somatic Cell
  • Chromosomal Localization
  • Cell Hybrid