Summary
Postmetaphase aberrations were significantly higher in cultures of human leukocytes treated with N, N, N′-tris-(2-chloroethyl)-N′, O-propylene phosphoric acid ester diamide (Z 4828) and N-(2-chloroethyl)-N′-(2-chloroethyl)-N′, O-propylene phosphoric acid ester diamide (Z 4942) than in untreated controls. The pattern of the intrachromosomal distribution of 1000 breaks each was significantly nonrandom. Clear clusters of breaks occured for instance in the distal segments of chromosomes numbered 1, 2, 4–5, 6–12 and X, and 13–15. Further experiments are necessary to interpret these data.
Zusammenfassung
Anaphase-Telophase-Aberrationen waren nach Einwirkung von N,N, N′-Tris-(2-chloräthyl)-N′, O-propylen-phosphorsäureester-diamid (Z 4828) und N-(2-Chloräthyl)-N′, O-propylen-phosphorsäureester-diamid (Z 4942) in Leukocytenkulturen signifikant höher als bei den Kontrollen. Das intrachromosomale Verteilungsmuster von jeweils insgesamt 1000 Brüchen war signifikant ungleichmäßig, besondere Häufungen traten unter anderem in den distalen Segmenten der Chromosomen 1, 2, 4–5, 6–12 und X und 13–15 auf. Zur Deutung dieses Befundes sind weitere Experimente erforderlich.
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Stopik, D., Hampel, K.E. Cytogenetische Untersuchungen mit zwei N-substituierten Endoxanabkömmlingen an menschlichen Leukocyten in vitro. Hum Genet 6, 61–68 (1968). https://doi.org/10.1007/BF00287155
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DOI: https://doi.org/10.1007/BF00287155