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Inactive normal X in a female leukaemic patient with an acquired X/autosome translocation

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Summary

An X;9;22 translocation was detected in bone marrow cells of a female patient with blastic crisis of CML. A dynamic study following 5-BrdU treatment showed that the inactive late-replicating X chromosome was the normal one. This pattern of X-chromosome replication appears to be superimposable on the most usual model found in congenital X/autosome translocations.

It is suggested that preferential autosome translocation onto the active X chromosome could be the general rule in acquired X/autosome translocations associated with long survival.

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Authors and Affiliations

  1. Cattedra di Genetica Medica, Università di Roma, Rome, Italy

    B. Dallapiccola

  2. Cattedra di Ematologia, Università di Roma, Rome, Italy

    Giuliana Alimena

Authors
  1. B. Dallapiccola
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  2. Giuliana Alimena
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Dallapiccola, B., Alimena, G. Inactive normal X in a female leukaemic patient with an acquired X/autosome translocation. Hum Genet 48, 169–177 (1979). https://doi.org/10.1007/BF00286900

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  • DOI: https://doi.org/10.1007/BF00286900

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