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Hb Sinai, a new α chain mutant a 47 His

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Summary

A new α chain mutant Hb-Sinai α47 His is described. The aminoacid composition of all tryptic peptides has been determined, with the exception of the insoluble core. In the fingerprint peptide T 6 which normally migrates between T 3 and T 1, moves now between T 3 and T 7. The aminoacid composition of peptide T 6 indicates a change in the aminoacid composition from Asp- to His+ in position 47.

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Literature

  • Beale, D., and H. Lehmann: Abnormal hemoglobins and the genetic code. Nature (Lond.) 207, 259–261 (1964).

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  • Clegg, J. B., M. A. Naughton, and D. J. Weatherall: Abnormal human hemoglobins. Separation and characterisation of the α and β chains by chromatography, and the determination of two new variants, Hb Chesapeake and Hb J (Bangkok). J. molec. Biol. 19, 91–108 (1966).

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Authors and Affiliations

  1. Max-Planck-Institut für experimentelle Medizin der Universität Göttingen, Göttingen, Germany

    W. Ostertag

  2. School of Medicine, Johns Hopkins University, Baltimore

    E. W. Smith

  3. Dept. of Medicine, The Johns Hopkins University School of Medicine, 21205, Baltimore, Md., USA

    E. W. Smith

Authors
  1. W. Ostertag
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  2. E. W. Smith
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Additional information

This work was supported by Grant No. GM 13714 U.S.P.H.S.

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Ostertag, W., Smith, E.W. Hb Sinai, a new α chain mutant a 47 His . Hum Genet 6, 377–379 (1968). https://doi.org/10.1007/BF00286809

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  • DOI: https://doi.org/10.1007/BF00286809

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