Summary
As compared with controls (25) an increased frequency of satellite association was observed in groups of mongoloid children (23), their parents (9) and in cases of Turner's syndrom (5) and treated hypothyreosis (9). The high incidence of associations in the group of mongoloids and in some of their parents may be explained with a possible simultaneous tendency to satellite association and nondisjunction. The high values in treated hypothyreosis could be the consequence of thyroxin action.
Zusammenfassung
In den Gruppen der Kinder mit Down-Syndrom (23), deren Eltern (9), der Kinder mit Turner-Syndrom (5) und behandelter Hypothyreose (9) wurden im Vergleich zu Kontrollen (25) erhöhte Satellitenassoziationswerte gefunden. Daß die Gruppe der Kinder mit Down-Syndrom und einige von deren Eltern vermehrt Assoziationen aufweisen, könnte mit einer mit erhöhter Satellitenassoziation einhergehenden Tendenz zu Chromosomenanomalien in Zusammenhang stehen. Die erhöhten Werte bei den behandelten Hypothyreosen könnten mit der Wirkung des Thyroxins erklärt werden.
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Mit Unterstützung der Schweizerischen Akademie der medizinischen Wissenschaften
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Luchsinger, U., Bühler, E., Méhes, K. et al. Satellitenassoziationen bei autosomalen und gonosomalen Chromosomenanomalien und bei Hypothyreosen. Hum Genet 8, 53–61 (1969). https://doi.org/10.1007/BF00286756
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DOI: https://doi.org/10.1007/BF00286756