Human Genetics

, Volume 83, Issue 2, pp 205–206 | Cite as

On the parental origin of the deletion in Angelman syndrome

  • Joan H. M. Knoll
  • Robert D. Nicholls
  • Marc Lalande
Letters to the Editors

References

  1. Cooke A, Tolmie JL, Glencross, FJ, Boyd E, Clarke MM, Day R, Stephenson JBP, Conner JM (1988) Detection of a de novo 15q deletion in a child with Angelman's syndrome by cytogenetic analysis and flow cytometry. J Med Genet 25:642Google Scholar
  2. Donlon TA (1988) Similar molecular deletions on chromosome 15q11.2 are encountered in both the Prader-Willi and Angelman syndromes. Hum Genet 80:322–328Google Scholar
  3. Jarman AP, Nicholls RD, Weatherall DJ, Clegg JB, Higgs DR (1986) Molecular characterisation of a hypervariable region downstream of the human α-globin gene cluster. EMBO J 5:1857–1863Google Scholar
  4. Kaplan LC, Wharton R, Elias E, Mandell F, Donlon T, Latt SA (1987) Clinical heterogeneity associated with deletions in the long arm of chromosome 15: report of 3 new cases and their possible significance. Am J Med Genet 28:45–53Google Scholar
  5. Knoll JHM, Nicholls RD, Magenis RE, Graham Jr JM, Lalande M, Latt SA (1989) Angelman and Prader-Willi syndromes share a common chromosome 15 deletion but differ in parental origin of the deletion. Am J Med Genet 32:285–290Google Scholar
  6. Nicholls RD, Knoll JH, Glatt K, Hersh JH, Brewster TD, Graham JM, Wurster-Hill D, Wharton R, Latt SA (1989) Restriction fragment length polymorphisms within proximal 15q and their use in molecular cytogenetics and the Prader-Willi syndrome. Am J Med Genet 33:66–77Google Scholar
  7. Williams CA, Donlon TA, Gray BA, Stone JW, Hendrickson JE, Cantu ES (1988) Incidence of 15q deletions in the Angelman's syndrome: a survey of fourteen affected patients. Am J Hum Genet 43:A75Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Joan H. M. Knoll
    • 1
    • 2
  • Robert D. Nicholls
    • 1
    • 2
    • 3
  • Marc Lalande
    • 1
    • 2
    • 3
  1. 1.Division of GeneticsThe Children's HospitalBostonUSA
  2. 2.Department of PediatricsHarvard Medical SchoolBostonUSA
  3. 3.Howard Hughes Medical InstituteBostonUSA

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