Summary
The level of N-acetoxy-2-acetylaminofluorene (NA-AAF)-induced unscheduled DNA synthesis and the level of covalent binding of NA-AAF to DNA were determined in the mononuclear leukocytes of monozygotic and diazygotic twin pairs (n=16 for each type). A statistically significant high degree of heritability was calculated for both parameters which, in turn, indicate genetic control of individual levels of induced DNA damage by NA-AAF.
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References
Atlas SA, Vesell ES, Nebert DW (1976) Genetic control of interindividual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes. Cancer Res 36: 4619–4630
Ellard GA, Mitcheson DA, Girling DJ, Nunn AJ, Fox W (1978) The hepatic toxicity of isoniazid among rapid and slow acetylators of the drug. Am Rev Respir Dis 118:628–629
Emery AEH, Anand R, Danfort D, Duncan W, Paton L (1978) Arylhydrocarbon-hydroxylase inducibility in patients with cancer. Lancet I:470–471
Guirgi HA, Lynch HT, Mate T, Harris RE, Wells I, Caha L, Anderson J, Maloney K, Rankin L (1976) Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls. Oncology 33:105–109
Jett JR, Moses HL, Branum EL, Taylor WF, Fontana RS (1978) Benzo(a)pyrene metabolism and blast transformation in peripheral blood mononuclear cells from smoking and nonsmoking populations and lung cancer patients. Cancer 41:192–200
Kellermann G, Luyten-Kellermann M, Shaw CR (1973a) Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes. Am J Hum Genet 25:327–331
Kellermann G, Shaw CR, Luyten-Kellermann M (1973b) Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. New Engl J Med 289:934–937
King CM, Weber WW (1981) Formation, metabolic activation by N,O-acyltransfer, and hydrolysis of N-acyl-N-arylamine derivatives. Natl Cancer Inst Monogr 58:117–122
Kouri RE, McKinney CE, Slomiany DJ, Snodgrass DR, Wray NP, McLemore TL (1982) Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes. Cancer Res 42:5030–5037
Lotlikar PD, Sook Hong Y (1981) Microsomal N- and C-oxidations of carcinogenetic aromatic amines and amides. Natl Cancer Inst Monogr 58:101–107
Medlund P, Cederlöf R, Floderus-Myrhed B, Friberg L, Sörensen S (1976) A new Swedish twin registry. Acta Medica Scand Suppl 600:1–111
Miall WE (1971) Heredity and hypertension. The Practitionet 207: 20–27
Miall WE, Oldham PD (1963) The hereditary factor in arterial blood-pressure. Br Med J 1:75–80
Mitchell JR, Zimmerman HJ, Ishak KG, Thorgeirsson UP, Timbrell JA, Snodgrass WR, Nelson SD (1976) Isoniazid liver injury: Clinical spectrum, pathology, and probable pathogenesis. Ann Int Med 84:181–192
Paigen B, Gurtoo HL, Minowada J Houten L, Vincent R, Paigen K, Parker NB, Ward E, Hayner NT (1977) Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk. New Engl J Med 297:346–350
Pero RW, Bryngelsson C, Mitelman F, Thulin T, Nordén Å (1976) High blood pressure related to carcinogen-induced unscheduled DNA synthesis, DNA carcinogen binding, and chromosomal aberrations in human lymphocytes. Proc Natl Acad Sci USA 73: 2496–2500
Pero RW, Bryngelsson C, Mitelman F, Kornfält R, Thulin T, Nordén Å (1978) Interindividual variation in the responses of cultured human lymphocytes to exposure from DNA damaging chemical agents. Mutat Res 53:327–341
Pero RW, Nordén Å (1981) Mutagen sensitivity in peripheral lymphocytes as a risk indicator. Environ Res 24:409–424
Pero RW, Bryngelsson T, Högstedt B, Åkesson B (1982a) Occupational and in vitro exposure to styrene assessed by unscheduled DNA synthesis in resting human lymphocytes. Carcinogenesis 3:6, 681–685
Pero RW, Bryngelsson T, Widegren B, Högstedt B, Welinder H (1982b) A reduced capacity for unscheduled DNA synthesis in lymphocytes from individuals exposed to propylene oxide and ethylene oxide. Mutat Res 104:193–200
Pero RW, Miller D, Lipkin M, Markowitz N, Gupta S, Winawer S, Enker W, Good R (1983) A reduced capacity for DNA repair synthesis in patients with or genetically predisposed to colorectal cancer. J Natl Cancer Inst 70 (5):867–875
Pero RW, Pero-Lund M (1983) The reproducibility of individual estimations in the covalent binding of N-acetoxy-2-acetyl-aminofluorene to DNA and in the induction of unscheduled DNA synthesis. Mutat Res 120:219–224
Platt R (1963) Heredity in hypertension. Lancet 1:899–904
Poirier MC, Yuspa SH (1981) Detection and quantitation of acetylated and deacetylated N-2-fluorenylacetamide-DNA adducts by radioimmunoassay. Natl Cancer Inst Monogr 58:211–216
Sarna S, Kaprio J, Sistonen P, Koskenvuo M, (1978) Diagnosis of twin zygosity by mailed questionnaire. Hum Hered 28:241–254
Trell E, Korsgaard R, Hood B, Kitzing P, Nordén G, Simonson BG (1976) Aryl hydrocarbon hydrozylase inducibility and laryngeal carcinomas. Lancet II:140–142
Weber WW (1973) Acetylation of drugs. In: Fishman WH (ed) Metabolic conjugation and metabolic hydrolysis, vol 3. New York, Academic Press, pp 249–296
Weinberg R, Avet LM, Gardner MJ (1976) Estimates of the heritability of serum lipoprotein and lipid concentrations. Clin Genet 9:588–592
Weisburger EK (1981) Metabolic studies in vivo with arylamines. Natl Cancer Inst Monogr 58:95–99
Vogel F, Buselmaier W, Reichert W, Kellermann G, Berg P (eds) (1978) Human genetic variation in response to medical and environmental agents: Pharmacogenetics and ecogenetics. Hum Genet Suppl 1:1–192
Vogel F, Motulsky AG (1982) Human genetics, problems and approaches. Springer, Berlin Heidelberg New York, pp 173–188 Appendix 6, pp 586–590
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Pero, R.W., Bryngelsson, C., Bryngelsson, T. et al. A genetic component of the variance of N-acetoxy-2-acetylaminofluorene-induced DNA damage in mononuclear leukocytes determined by a twin study. Hum Genet 65, 181–184 (1983). https://doi.org/10.1007/BF00286659
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DOI: https://doi.org/10.1007/BF00286659