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Effect of solvents on in vitro pesticides inhibition of atpase in certain tissues of Labeo rohita

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Abstract

This paper deals with the effect of solvents on the pesticide inhibition of ATPase in the gills and brains of a freshwater teleost Labeo rohita after in vitro treatment with chlordane (an organochlorine pesticide) and MetasystoxR (an organophosphate) pesticide after dissolving in different organic solvents viz. benzene, cyclohexane, cyclopentane, dimethylacetamide (DMA), dimethylformamide (DMF), dimethylsulfoxide (DMS), and acetone/ethanol (1:1) mixture. The inhibitory effect of chlordane was greatly reduced by cyclohexane, cyclopentane and benzene, to a less extent by DMA, DMF, and DMS and to a lesser extent by acetone/ethanol (1:1) mixture. ATPase inhibition by MetasystoxR showed less effect on the inhibition of ATPase activities. Effect on the inhibition of Na+, K+-ATPase was observed to be greater than on Mg++ ATPase in both tissues, but the activity of both the ATPase in gill homogenate was decreased compared to brain homogenate. Choice of solvents can have profound effects on the response of ATPase to chlorinated hydrocarbon pesticides.

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Authors and Affiliations

  1. Pollution Relevant Research Laboratory (P.B. 264), Department of Zoology, D.A.V. College, 251001, Muzaffarnagar, India

    R. C. Dalela, S. K. Bansal, A. K. Gupta & S. R. Verma

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  1. R. C. Dalela
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  2. S. K. Bansal
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  3. A. K. Gupta
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  4. S. R. Verma
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Dalela, R.C., Bansal, S.K., Gupta, A.K. et al. Effect of solvents on in vitro pesticides inhibition of atpase in certain tissues of Labeo rohita . Water Air Soil Pollut 11, 201–205 (1979). https://doi.org/10.1007/BF00286631

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  • DOI: https://doi.org/10.1007/BF00286631

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