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Acetazolamide treatment of progressive hydrocephalus secondary to intraventricular hemorrhage in a preterm infant

Abstract

Progressive hydrocephalus in the preterm infant requires judicious management. Fortunately, in some infants, short-term treatment may obviate the need for shunting procedures. This case illustrates the successful control of progressive hydrocephalus in a preterm infant managed by acetazolamide, a carbonic anhydrase inhibitor. The drug was discontinued transiently early in the course of treatment. This patient's clinical course, change in head circumference, and cerebral utrasound provide evidence of the benefit of this drug regimen in treating hydrocephalus.

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References

  1. Donat JF (1980) Acetazolamide induced improvement in hydrocephalus. Arch Neurol 37:376

    Google Scholar 

  2. Huttenlocher PR (1965) Treatment of hydrocephalus with acetazolamide. J Pediatr 66:1023–1030

    Google Scholar 

  3. Mealy J Jr, Barker DJ (1968) Failure of oral acetazolamide to avert hydrocephalus in infants with myelomeningocele. J Pediatr 72:257–259

    Google Scholar 

  4. Palma PA, Morriss FH, Miner ME, Denson SF, Adcock EW (1979) Prospective survey of intraventricular hemorrhage in infants less than 1800 grams. Clin Res 27:815A

    Google Scholar 

  5. Rubin RC, Henderson ES, Ommaya A, Walker MD, Rall DP (1966) The production of cerebrospinal fluid in man and its modification by acetazolamide. J Neurosurg 25:430–436

    Google Scholar 

  6. Schain RJ (1969) Carbonic anhydrase inhibitors in chronic infantile hydrocephalus. Am J Dis Child 117:621–626

    Google Scholar 

  7. Volpe JJ (1979) Intracranial hemorrhage in the newborn: current understanding and dilemmas. Neurology 29:632–636

    Google Scholar 

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Miner, M.E. Acetazolamide treatment of progressive hydrocephalus secondary to intraventricular hemorrhage in a preterm infant. Child's Nerv Syst 2, 105–106 (1986). https://doi.org/10.1007/BF00286232

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  • DOI: https://doi.org/10.1007/BF00286232

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