Summary
1-Acetoxypropylpropylnitrosamine (1-APPN) was synthesized and its biological effect examined in Syrian hamsters after subcutaneous (s.c.) administration. 1-APPN induced mesenchymal and epithelial neoplasms at the injection sites, as well as epithelial tumors in remote organs. Local neoplasms were s.c. sarcomas, mammary adenocarcinomas and Schwannomas, whereas tumors of the respiratory tract (papillary polyps, papillomas, adenomas, epidermoid carcinomas, and adenocarcinomas) were attributed to a systemic effect as were pancreas duct tumors. Neoplasms which originated in the upper digestive and genital tracts of females (papillomas, epidermoid carcinomas) may be related to a systemic and local effect of 1-APPN.
Zusammenfassung
Die biologische Wirkung von 1-Acetoxypropylpropylnitrosamine (1-APPN) wurde an Syrischen Hamstern nach subcutaner Gabe überprüft. 1-APPN induzierte sowohl mesenchymale und epitheliale Geschwülste an der Injektionsstelle wie auch epitheliale Tumoren in entfernt liegenden Organen. Lokale Neoplasmen erwiesen sich als subcutane Sarcome, Adenocarcinome der Mamma und Schwannome, während Tumoren des Respirationstraktes (papilläre Polypen, Papillome, Adenome, Plattenepithelcarcinome, Adenocarcinome) wie auch der Pankreasgänge einer systemischen Wirkung entsprachen. Neoplasmen des oberen Verdauungstrakts und des Genitaltrakts weiblicher Hamster (Papillome, Plattenepithelcarcinome) sind möglicherweise Folge sowohl systemischer wie lokaler Wirkung von 1-APPN.
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References
Althoff,J., Krüger,F.F., Hilfrich,J., Schmähl,D., Mohr,U.: Carcinogenicity of β-hydroxylated dipropylnitrosamine. Naturwissenschaften 60, 55 (1973)
Althoff,J., Krüger,F.W., Mohr,U.: Carcinogenic effect of dipropylnitrosamine and compounds related by β-oxidation. J. Natl. Cancer Inst. 51, 287–288 (1973)
Blattmann,L., Preussmann,R.: Struktur von Metaboliten carcinogener Dialkylnitrosamine im Rattenurin. Z. Krebsforsch. 79, 3–5 (1973)
Druckrey,H.: Chemical carcinogenesis of N-nitroso derivatives. Gann 17, 107–132 (1975)
Druckrey,H., Preussmann,R., Ivankovic,S., Schmähl,D.: Organotrope carcinogene Wirkung bei 65 verschiedenen N-Nitrosoverbindungen an BD-Ratten. Z. Krebsforsch. 69, 103–201 (1967)
Gingell,R., Wallcave,L., Nagel,D., Kupper,R., Pour,P.: Metabolism of pancreatic carcinogens N-nitroso-bis(2-oxypropyl)amine and N-nitroso-bis(2-hydroxypropyl)amine in the Syrian hamster. J. Natl. Cancer Inst. (in press)
Halberstaedter,L.: A benzpyrene tumor strain in hamsters with tendency to metastasis formation. Nature (Lond.) 144, 377–378 (1939)
Herrold,K.M.: Carcinogenic effect of N-methyl-N-nitrosourea administered subcutaneously. J. Path. Bact. 92, 35–41 (1966)
Krüger,F.W.: Metabolismus von Nitrosaminen in vivo. Z. Krebsforsch. 76, 145–154 (1971)
Krüger,F.W., Pour,P., Althoff,J.: Induction of pancreas tumors by di-isopropanolnitrosamine. Naturwissenschaften 61, 328 (1974)
Magee,P.N., Barnes,J.M.: Carcinogenic nitroso compounds. Adv. Cancer Res. 10, 163 (1967)
Nettelship,A., Smith,A.G.: Studies on the early phase of induced fibrosarcoma in the hamster. Proc. Soc. Exp. Biol. (N. Y.) 74, 800–802 (1950)
Pour,P., Althoff,J., Gingell,R., Kupper,R., Krüger,F.W., Mohr,U.: A further pancreatic carcinogen in Syrian golden hamsters: N-nitroso-bis(2-acetoxypropyl)amine. Cancer Letters 1, 197–202 (1976)
Pour,P., Althoff,J., Krüger,F.W., Schmähl,D., Mohr,U.: Induction of pancreatic neoplasms by 2,2′-dioxopropylnitrosamine. Cancer Letters 1, 3–6 (1975)
Pour,P., Krüger,F.W., Althoff,J., Cardesa,A., Mohr,U.: Effect of β-oxidized nitrosamines on Syrian hamsters 3. 2,2′-Dihydroxy-n-propylnitrosamine. J. Natl. Cancer Inst. 54, 141–146 (1975)
Preussmann,R., Daiber,D., Hengy,H.: A sensitive colour reaction for nitrosamines in thin layer chromatography. Nature 201, 502 (1964)
Rice,J.M., Joshi,S.R., Roller,P.P., Wenk,M.L.: Methyl(acetoxymethyl)nitrosamine: a new carcinogen highly specific for colon and small intestine. Proc. Amer. Ass. Cancer Res. 66, 128 (1975)
Roller,P.P., Shimp,D.A., Keefer,L.: Synthesis and solvolysis of methyl(acetoxymethyl)nitrosamine. Tetrahedron Letters 2065–2068 (1975).
Shubik,P., Della Porta,G., Pietra,G., Tomatis,L., Rappaport,H., Saffiotti,U., Toth,B.: Factors determining the neoplastic response induced by carcinogens. In: Biological interactions in normal and neoplastic growth, pp. 285–297. New York: Little, Brown, and Co. (Inc.) 1962
Weil,C.S.: Tables for convenient calculation of median effective dose (LD50 or ED50) and instructions in their use. Biometrics 8, 249–263 (1952)
Wiessler,M.: Synthesis of α-functional nitrosamines. Angew. Chem. 13, 743–744 (1974)
Wiessler,M., Schmähl,D.: Zur carcinogenen Wirkung von N-Nitrosoverbindungen. Z. Krebsforsch. 85, 47–49 (1976)
Wodinsky,I., Helinski,A., Kensler,C.J.: Susceptibility of Syrian hamsters to induction of fibrosarcoma with a single injection of 3,4,9,10-dibenzpyrene. Nature (Lond.) 203, 308–309 (1960)
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Supported by Public Health Service contract NO1 CP 33278 from the Division of Cancer Cause and Prevention, the National Cancer Institute
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Althoff, J., Grandjean, C., Pour, P. et al. Local and systemic effects of 1-Acetoxypropylpropylnitrosamine in Syrian golden hamsters. Z. Krebsforsch. 90, 127–140 (1977). https://doi.org/10.1007/BF00285319
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DOI: https://doi.org/10.1007/BF00285319