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Kinetic study on the effects of acidic polysaccharides on the interaction of fibrinogen and thrombin

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Summary

Retardation effect of acidic polysaccharides on the interactions of fibrinogen with thrombin was kinetically investigated by measuring the turbidity as a measure of the concentration of fibrin polymer formed in the system. To this aim, the fibrinogenfibrin conversion curve was analyzed kinetically based on the elementary reactions, and the slope and the induction period of the conversion curve were expressed as functions of the concentrations of fibrinogen, thrombin, and polysaccharide. The strong retardation effect of dextran sulfate and heparin was quantitatively interpreted. Seven kinds of polysaccharides were examined.

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Nakanishi, E., Sato, H. & Nakajima, A. Kinetic study on the effects of acidic polysaccharides on the interaction of fibrinogen and thrombin. Polymer Bulletin 3, 655–664 (1980). https://doi.org/10.1007/BF00285302

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  • DOI: https://doi.org/10.1007/BF00285302

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