Summary
Currently available results on chromosome analyses of human tumors and leukemias are summerized. Results indicate that with the exception of the Philadelphia-chromosome (Ph1) in chronic myelocytic leukemia no chromosomal anomalies in any other neoplastic disease became known which have diagnostic or prognostic significance. Aneuploidy of tumor cells should not be considered an absolute criterium for malignancy of such cells.
Zusammenfassung
Es wird ein kurzer Überblick über die derzeit verfügbaren Ergebnisse der Chromosomenanalyse menschlicher Tumoren und Hämoblastosen gegeben. Diese Ergebnisse besagen, daß es mit Ausnahme des Philadelphia-Chromosoms (Ph1) in chronisch myeloischer Leukämie in keiner anderen neoplastischen Erkrankung des Menschen Chromosomenanomalien gibt, die diagnostische und prognostische Bedeutung haben. Die Aneuploidie von Tumorzellen sollte nicht als absolutes Kriterium der Malignität solcher Zellen bewertet werden.
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Literatur
Atkin,N.B., Baker,M.C.: Chromosome abnormalities as primary events in human malignant disease: Evidence from marker chromosomes. J. Nat. Cancer Inst. 36, 539–551 (1966).
—: Modal DNA value and chromosome number in ovarian neoplasia. Cancer 27, 1064–1073 (1971).
Berger,R.: Chromosomes et tumeurs humaines. Path.-Biol. 17, 1133–1151 (1969).
Enterline,H.T., Arvan,D.A.: Chromosome constitution of adenoma and adenocarcinoma of the colon. Cancer 20, 1746–1759 (1967).
Ezdinli,E.Z., Sokal,J.E., Crosswhite,L.H., Sandberg,A.A.: Ph1/(s-)-positive and Ph1/(s-)-negative chronic myelocytic leukemia. Ann. intern. Med. 72, 175–182 (1970).
Falor,W.H.: Chromosomes in noninvasive papillary carcinoma of the bladder. J. Amer. Med. Ass. 216, 791–794 (1971).
Hossfeld,D.K., Sandberg,A.A.: Das Philadelphia Chromosom. Klin. Wehr. 48, 1431–1441 (1970).
—, Tin Han, Holdsworth,R.N., Sandberg,A.A.: Chromosomes and causation of human cancer and leukemia. VII. The significance of the Ph1 in conditions other than CML. Cancer 27, 186–192 (1971).
Houston,E.W., Ritzmann,S.E., Levin,W.C.: Chromosomal aberrations common to three types of monoclonal gammopathies. Blood 29, 214–232 (1967).
Ishihara,T., Kikuchi,Y., Sandberg,A.A.: Chromosomes of twenty cancer effusions: Correlation of karyotypic, clinical, and pathologic aspects. J. nat. Cancer Inst. 30, 1303–1361 (1963).
Lubs,H.A., Kotler,S.: The prognostic significance of chromosome abnormalities in colon tumors. Ann. intern. Med. 67, 328–336 (1967).
Makino,S.: The concept of stemline-cells as progenitors of a neoplastic population. Proc. Internal. Genet. Symposia, 177–181 (1956).
—, Sasaki,M.S., Tonomura,A.: Cytological studies of tumors. XL. Chromosome studies in fifty-two human tumors. J. nat. Cancer Inst. 32, 741–763 (1964).
Millard,R.E.: Chromosome abnormalities in the malignant lymphomas. European J. Cancer 4, 97–105 (1968).
Sandberg,A.A., Ishihara,T., Kikuchi,Y., Crosswhite,L.H.: Chromosomes of lymphosarcoma and cancer cells on bone marrow. Cancer 17, 738–746 (1964).
—, Yamada,K., Kikuchim,Y., Takagi,N.: Chromosomes and causation of human cancer and leukemia. III. Karyotypes of cancerous effusions. Cancer 20, 1099–1116 (1967).
—, Hossfeld,D.K.: Chromosomal abnormalities in human neoplasia. Ann. Rev. Med. 21, 379–408 (1970).
Siebner,H.: Chromosomenuntersuchung bei malignen Erkrankungen des lymphoplasmoreti kulären Systems mit besonderer Berücksichtigung der Paraproteinämie. Ärztl. Forsch. 21, 359–381 (1967).
Singer,H., Zang,K.D.: Zytologische und zytogenetische Untersuchungen an Hirntumoren. I. Die Chromosomenpathologie des menschlichen Meningeoms. Humangenetik 9, 172–184, (1970).
Slot,E.: A karyologic study of the cancer of the ovary and the cancer cells in the ascitic effusions. Neoplasma 14, 3–10, (1967).
Spriggs,A.I., Boddington,M.M.: Chromosomes of Sternberg Reed cells. Lancet 1962 II, 153.
—, Bowey,C.E., Cowdell,R.H.: Chromosomes of precancerous lesions of the cervix uteri. New data and a review. Cancer 27, 1239–1254 (1971).
Toews,H.A., Katayama,K.P., Masukawa,T., Lewison,E.F.: Chromosomes of benign and malignant lesions of the breast. Cancer 22, 1296–1307 (1968).
Whang-Peng,J., Freireich,E.J., Oppenheim,J.J., Frei,E.III, Tjio,J.H.: Cytogenetic studies in 45 patients with acute lymphocytic leukemia. J. Nat. Cancer Inst. 42, 881–897 (1969).
—, Henderson,E.S., Knutson,T., Freireich,E.J., Cart,J.J.: Cytogenetic studies in acute myelocytic leukemia with special emphasis on the occurrence of Ph1-chromosome. Blood 34, 448–457 (1970).
Yamada,K., Takagi,N., Sandberg,A.A.: Chromosomes and causation of human cancer and leukemia. II. Karyotypes of human solid tumors. Cancer 19, 1879–1890 (1966).
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Hossfeld, D.K. Chromosomenverhalten in neoplastischen Erkrankungen des Menschen. Z. Krebsforsch. 78, 123–128 (1972). https://doi.org/10.1007/BF00285257
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DOI: https://doi.org/10.1007/BF00285257