Summary
The expression of the ETS-2 proto-oncogene, located on chromosome 21, in normal fetal tissues and in neural tissue of a fetus affected by Down syndrome has been investigated. The results show that the ETS-2 proto-oncogene is expressed in almost all the tissues examined and that it is transcribed at constant levels in neural tissue between the 13th and 24th weeks. ETS-2 experession appeared to be slightly increased in Down syndrome brain compared with that of normal controls of the same gestational age.
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Baffico, M., Perroni, L., Rasore-Quartino, A. et al. Expression of the human ETS-2 oncogene in normal fetal tissues and in the brain of a fetus with trisomy 21. Hum Genet 83, 295–296 (1989). https://doi.org/10.1007/BF00285177
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DOI: https://doi.org/10.1007/BF00285177