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Not all chromosome imbalance resulting from the 11q;22q translocation is due to 3:1 segregation in first meiosis

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Summary

The constitutional translocation between chromosomes 11 and 22 [t(11;22)(q23.3;q11.22)] is one of the best known rearrangements in the human genome. Hitherto only one type of unbalanced karyotype, namely 47,XX or XY,+der(22) t(11;22)(q23.3;q11.2) was found among offspring of the translocation carriers. This result is the product of a 3:1 segregation at meiosis. We report an alternative unbalanced karyotype. The proband's karyotype is 47,XY,t(11;22)(123.3;q11.2), +der(22)t(11;22)(q23.3;q11.2)pat. This finding cannot be due to nondisjunction in first meiosis of the translocation carrier.

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Authors and Affiliations

  1. The Genetics Center of Southwest Biomedical Research Institute, 6401 East Thomas Road, 85251, Scottsdale, AZ, USA

    David H. Lockwood, Anna Farrier, Frederick Hecht & Judith Allanson

  2. Cancer Center of Southwest Biomedical Research Institute, 6401 East Thomas Road, 85251, Scottsdale, AZ, USA

    David H. Lockwood, Anna Farrier, Frederick Hecht & Judith Allanson

Authors
  1. David H. Lockwood
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  2. Anna Farrier
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  3. Frederick Hecht
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  4. Judith Allanson
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Lockwood, D.H., Farrier, A., Hecht, F. et al. Not all chromosome imbalance resulting from the 11q;22q translocation is due to 3:1 segregation in first meiosis. Hum Genet 83, 287–288 (1989). https://doi.org/10.1007/BF00285174

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  • DOI: https://doi.org/10.1007/BF00285174

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