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Meiosis in a male with Down's syndrome

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Summary

The chromosomes in mitotic and meiotic phases were investigated in a male Down's syndrome case, aged 45. Information was obtained that based on blood and tunica vaginalis cultures, the somatic chromosome complement was found to possess 47 chromosomes with the standard 21-trisomy, and further that the majority of cells from biopsied testicular specimens examined showed the chromosome number 47 in spermatogonia, and 22 autosomal elements consisting of 21 bivalents and a trivalent, together with an X-Y bivalent in the first spermatocytes. The seminiferous tubules contained no mature spermatozoa.

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Authors and Affiliations

  1. Zoological Institute, Hokkaido University, Sapporo, Japan

    Motomichi Sasaki

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  1. Motomichi Sasaki
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Contribution No. 688 from the Zoological Institute, Faculty of Science, Hokkaido University, Sapporo. This paper is dedicated to Professor Sajiro Makino, Zoological Institute, Hokkaido University, Sapporo, in honor of his sixtieth birthday, June 21, 1966.

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Sasaki, M. Meiosis in a male with Down's syndrome. Chromosoma 16, 652–657 (1965). https://doi.org/10.1007/BF00285114

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  • DOI: https://doi.org/10.1007/BF00285114

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