Skip to main content
Log in

Serum and whole blood of rats resistant or sensitive to Jensen tumor effect on the acceptance (taking) and growth of Jensen tumor grafts

  • Published:
Zeitschrift für Krebsforschung und Klinische Onkologie Aims and scope Submit manuscript

Summary

The results obtained by concomitent inoculation of four kinds of homologous sera or blood into Wistar and Long Evans rats grafted with Jensen tumors are analysed as regards taking and growth of the grafts. The four kinds are: 1. serum from rats naturally resistant to Jensen graft (R1); 2. serum from rats that became resistant to Jensen graft after the initial tumor graft was excised (R2); 3. serum from normal sensitive rats (S); 4. serum from tumorbearing rats in an advanced stage of development (B). Experiments were repeated four times. All sera proved to stimulate tumor takes and growth, but that effect was more obvious with the serum or blood from rats naturally resistant to Jensen tumor (R l ). The results are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Andrian,T., Corneci,I.: Experimental investigations on anticancerous immunotherapie in the rat with immune competent cells. Oncol. Radiol. 5, 423 (1971)

    Google Scholar 

  2. Hellström,I., Sjögren,H.O., Warner,G., Hellström,K.E.: Blocking of cell-mediated tumor immunity by sera from patients with growing neoplasms. Int. J. Cancer 7, 226 (1971)

    Google Scholar 

  3. Hutckin,P.: Mechanism and functions of immunologic enhancement, Surg. Gynec. Obstet. 1331, (1967)

  4. Jensen,C.O.: Übertragbare Ratten Sarkome. Krebsforsch. 7, 45 (1909)

    Google Scholar 

  5. Lupu,A.: Hereditary transmission of a resisting factor towards Jensen tumor (rat sarcoma), p. 260. Ist National Conference of animal Genetics, Bucharest, 10–12. XII. 1970

  6. Mihăescu,Gh.F., Mihaescu,I.F.: Rezultatele obtinute prin aplicarea unui model de immunoterapie experimentală a tumorii Ehrlich cu ser heterolog bivalent si vaccinare indirecta, Oncol. Radiol. 11, 39, (1972)

    Google Scholar 

  7. Mihăescu,Gh., Micu,N., Popp,I., Comisel,V., Mihăescu,I.: Treatment of ascite tumors with cytolytio serum obtained by double immunization, Neoplasma 1973 (in press)

  8. Mureşan,A., Simu,G.: Problema toxinei canceroase (toxohormonul). Oncol. Radiol. 1, 385 (1962)

    Google Scholar 

  9. Nakahara,W.: A chemical basis for tumor-host relations. J. nat. Cancer Inst. 24, 77 (1960)

    Google Scholar 

  10. Oprescu,C.C.: Exista o imunitate anticanceroasă? Progresele stiintei, Bucuresti: Acad. R.S.R. 1972. Vol. 5 8, 411

  11. Osswald,H.: Zur Behandlung transplantabler Tumoren mit cytotoxischen Verbindungen, S. 128, Symposium über Krebsprobleme, 27–28. VI. 1960, Düsseldorf — Berlin — Göttingen — Heidelberg. Springer 1961

    Google Scholar 

  12. Sticker,A. Die Immunität und die spontane Heilung der Krebskrankheit nach der Ergebnissen der modernen experimentellen Forschung. Z. Krebsforsch. 7, 55 (1909)

    Google Scholar 

  13. Voisin,G.A.: Immunological facilitation — a broadening of the enhacement phenomenon, Progr. Allergy 15, 328 (1971)

    Google Scholar 

  14. Winter,M., Bruhis,S., Klein,R., Moldovan,E., Bartoc,R.: Electrophoresis of sera from resistant, sensitive and Jensen tumor bearing rats, Personal Communication 1972

  15. Zilber,L.A.: Bazele immunologiei, Ed. Medicală, Bucuresti, 1959, p. 566, Translation from Russian 3 rd edition, 1956, Moscow

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lupu, A., Andrian, T. & Purcaroiu, D. Serum and whole blood of rats resistant or sensitive to Jensen tumor effect on the acceptance (taking) and growth of Jensen tumor grafts. Z. Krebsforsch. 87, 27–36 (1976). https://doi.org/10.1007/BF00285070

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00285070

Keywords

Navigation