Summary
Malaysians of Malay, Chinese, and Indian ancestries were electrophoretically phenotyped for Amy1 and saliva esterase region 1(Set-1) from saliva, Amy2 from plasma, soluble and mitochondrial GOT and PGM 3 from leukocyte and placenta. Kadazans and Bajaus, the indigenous people of Sabah, East Malaysia were surveyed for Amy2. Three types of variants were observed for Amy1, one type for Amy2. Only Indians were found to be polymorphic for Amy1. Two GOT s 2-1 and three GOT m 2-1 variants were found among 281 Chinese while three GOT m 2-1 variants were found among 311 Malays.
Malaysian Malays, Chinese, and Indians were found to be polymorphic for Set-1 and PGM 3. The gene frequencies in Malays are Set-1F=0.601±0.021, Set-1S=0.399±0.021; PGM 13 =0.788±0.020, PGM 23 =0.212±0.020; in Chinese Set-1F=0.497±0.028, Set-1S=0.503±0.028; PGM 13 =0.745±0.024, PGM 23 =0.255±0.024; in Indians, Set-1F=0.449±0.031, Set-1S=0.551±0.031; PGM 13 =0.755±0.029, PGM 23 =0.245±0.029.
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Balakrishnan, C. R., Ashton, G. C.: Polymorphisms of human salivary proteins. Am. J. Hum. Genet. 26, 145–153 (1974)
Boettcher, B., Lande, F. A. de la: Electrophoresis of human saliva and identification of inherited variants of amylase isozymes. Aust. J. exp. Biol. med. Sci. 47, 97–103 (1969)
Chen, S.-H., Giblett, E. R.: Genetic variation of soluble glutamic-oxaloacetic transaminase in man. Am. J. hum. Genet. 23, 419–424 (1971)
Davidson, R. G., Cortner, J. A., Rattazzi, M. C., Ruddle, F. H., Lubs, H. A.: Genetic polymorphisms of human mitochondrial glutamic oxaloacetic transaminase. Science 169, 391–393 (1970)
Fleischer, G. A., Potter, C. S., Wakim, K. G.: Separation of 2 glutamic-oxaloacetic transaminase by paper electrophoresis. Proc. Soc. Exp. Biol. Med. 103, 229–231 (1960)
Goedde, H. W., Stahn, M.: PGM 3 (PGM 1, PGM 2) phenotyping in human leucocytes with a simplified method. Humangenetik 22, 243–245 (1974)
Hackel, E., Hopkinson, D. A., Harris, H.: Population studies on mitochondrial glutamic-oxaloacetic transaminase. Ann. hum. Genet. (Lond.) 35, 491–496 (1972)
Hopkinson, D. A., Harris, H.: A third phosphoglucomutase locus in man. Ann. hum. Genet. (Lond.) 31, 359–367 (1968)
Ishimoto, G.: Placental phosphoglucomutase in Japanese. Jap. J. hum. Genet. 14, 183–188 (1969)
Kamarýt, J., Laxová, R.: Amylase heterogeneity. Some genetic and clinical aspects. Humangenetik 1, 579–586 (1965)
Kamarýt, J., Laxová, R.: Amylase heterogeneity variants in man. Humangenetik 3, 41–45 (1969)
Lamm, L. U.: Family population and mother-child studies of two phosphoglucomutase loci (PGM 1 and PGM 3): Lack of close linkage between the two loci (ω>0.33). Hum. Hered. 20, 292–304 (1970)
Merritt, A. D., Rivas, M. L., Bixler, D., Newell, R.: Salivary and pancreatic amylase: Electrophoretic characterizations and genetic studies. Am. J. hum. Genet. 25, 510–522 (1973)
Spencer, G., Hopkinson, D. A., Harris, H.: Phosphoglucomutase polymorphism in man. Nature 204, 742–745 (1964)
Tan, S. G.: Human saliva esterases: Genetic studies. Hum. Hered. 26, 207–216 (1976)
Ward, J. C., Merritt, A. D., Bixler, D.: Human salivary amylase: Genetics of electrophoretic variants. Am. J. hum. Genet. 23, 403–409 (1971)
Wolf, R. O., Taylor, L. L.: Isoamylases of human parotid saliva. Nature 213, 1128–1129 (1967)
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Teng, Y.S., Tan, S.G., Lopez, C.G. et al. Genetic markers in Malaysians: Variants of soluble and mitochondrial glutamic oxaloacetic transaminase and salivary and pancreatic amylase, phosphoglucomutase III and saliva esterase polymorphisms. Hum Genet 41, 347–354 (1978). https://doi.org/10.1007/BF00284769
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DOI: https://doi.org/10.1007/BF00284769