Skip to main content
SpringerLink
Log in

Analysis of the HLA-ABC linkage disequilibrium: Decreasing strength of gametic association with increasing map distance

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

1242 HLA-ABC haplotypes of the North German population (Hamburg) as deduced by family analyses are described. They are in perfect agreement with recently published data by Mayr (1977) from Austria (Vienna) in all parameters tested: frequency of the single HLA-alleles, haplotype distribution and linkage disequilibrium values. Gametic association studies revealed that 69.4% of the B and C genes (map distance 0.2 cM) 36.9% of the A and C genes (0.6 cM), but only 23.2% of the A and B genes (0.8 cM) were significantly more often combined than expected due to their frequencies. From these findings it seems likely that the linkage disequilibrium within the MHC is rather due to a short evolutionary period than to selective forces. Some observations as to the most common European haplotype A1,B8 are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Albert, E. D., Rittner, C., Grosse-Wilde, H., Netzel, B., Scholz, S.: Recombination frequency and linkage disequilibrium between HL-A and Bf. In: Histocompatibility testing 1975, F. Kissmeyer-Nielsen, ed., pp. 941–944. Copenhagen: Munksgaard 1975

    Google Scholar 

  • Bender, K., Mayerová, A., Hiller, C.: HLA-System. In: Handbuch der Humangenetik, P. E. Becker, ed., pp. 267–317. Stuttgart: Thieme 1975

    Google Scholar 

  • Bender, K., Mayerová, A., Frank, R., Hiller, C., Wienker, T.: Haplotype analysis of the linkage group HLA-A: HLA-B: Bf and its bearing on the interpretation of the linkage disequilibrium. Hum. Genet. 36, 191–196 (1977)

    Google Scholar 

  • Bodmer, W. F.: Population genetics of the HL-A system: retrospect and prospect. In: Histocompatibility testing, J. Dausset, J. Colombani, eds., pp. 611–617. Copenhagen: Munksgaard 1972

    Google Scholar 

  • Bodmer, W. F.: Report of the committee on the genetic constitution of chromosome 6. Baltimore Conference (1975): Third international Workshop on Human Gene Mapping. Birth Defects: Orig. Art. Ser. XII 7, pp. 24–30. New York: The National Foundation 1976

    Google Scholar 

  • Breuning, M. H., Berg-Loonen, E. M. van den, Bernini, L. F., Bijlsma, J. B., Loghem, E. von, Nijenhuis, L. E.: Localization of HLA on the short arm of chromosome 6. Hum. Genet. 37, 131–139 (1977)

    Google Scholar 

  • Ceppellini, R.: Old and new facts and speculations about transplantation antigens in man. Progr. Immunol., pp. 953–1025. New York: Academic Press 1971

    Google Scholar 

  • Fisher, R. A.: The logic of inductive inference. J. Roy. Statist. Soc. Ser. A 98, 39–54 (1935)

    Google Scholar 

  • Francke, U., Pellegrino, M. A.: Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6. Proc. Natl. Acad. Sci. USA 74, 1147–1151 (1977)

    Google Scholar 

  • Kaakinen, A., Helgesen, A., Nousiainen, H., Solheim, B. G., Thorsby, E.: The HLA-D determinants. A population study of Norwegians. Immunogenetics 4, 205–211 (1977)

    Google Scholar 

  • Kissmeyer-Nielsen, F., Kjerbye, K. E.: Lymphocytotoxic microtechnique, purification of lymphocytes by flotation. In: Histocompatibility testing 1967, E. S. Curtoni, P. L. Mattiuz, R. M. Tosi, eds., pp. 381–383. Copenhagen: Munksgaard 1967

    Google Scholar 

  • Lamm, L. U., Friedrich, U., Petersen, G. B., Jørgensen, J., Nielsen, J., Therkelsen, A. J., Kissmeyer-Nielsen, F.: Assignment of the major histocompatibility complex to chromosome 6 in a family with a pericentric inversion. Hum. Hered. 24, 273–284 (1974)

    Google Scholar 

  • Mayerová, A., Ropers, H. H., Grezeschik, K. H.: Localization of the HLA genes to the short arm of chromosome 6 using man-mouse somatic cell hybrids. Winnipeg Conference (1977): Fourth International Workshop on Human Gene Mapping (in press, 1977)

  • Mayr, W. R.: HLA-A,B,C gene and haplotype frequencies in Vienna. An analysis of family data. Hum. Genet. 37, 41–48 (1977)

    Google Scholar 

  • Shreffler, D. C., David, C. S., Passmore, H. C., Klein, J.: Genetic organization and evolution of the mouse H-2 region: A duplication model. Transplant. Proceed. 3, 176–179 (1971)

    Google Scholar 

  • Yates, F.: Contingency tables involving small numbers and X2-test. J. Roy. Statist. Soc. Suppl. Ser. B1, 217–235 (1934)

Download references

Author information

Authors and Affiliations

  1. Institut für Medizinische Mikrobiologie der Universität Hamburg, Martinistraße 52, D-2000, Hamburg 20, Federal Republic of Germany

    C. Hiller & Marlies Bischoff

  2. Institut für Humangenetik und Anthropologie der Universität Freiburg, Albertstraße 11, D-7800, Freiburg, Federal Republic of Germany

    Anita Schmidt & K. Bender

Authors
  1. C. Hiller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marlies Bischoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anita Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Bender
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hiller, C., Bischoff, M., Schmidt, A. et al. Analysis of the HLA-ABC linkage disequilibrium: Decreasing strength of gametic association with increasing map distance. Hum Genet 41, 301–312 (1978). https://doi.org/10.1007/BF00284764

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00284764

Keywords

Search

Navigation