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Zur carcinogenen Wirkung von N-Nitroso-Verbindungen

6. Mitteilung: Methoxymethyl-methylnitrosamin, 1-(Methoxy)-äthyl-äthylnitrosamin, Methoxymethyl-äthylnitrosamin, 1-(Methoxy)-äthyl-methylnitrosamin und N-Nitrosooxazolidin

On the carcinogenic action of N-nitroso compounds

6th communication: Methoxymethyl-methylnitrosamine, 1-(Methoxy)-ethyl-ethylnitrosamine, Methoxymethyl-ethylnitrosamine, 1-(Methoxy)-ethyl-methylnitrosamine, and N-nitrosooxazolidine

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Summary

The compounds mentioned in the title were tested for carcinogenicity in rats. All compounds proved to be carcinogens which showed interesting differences above all in the organotropy of action and in the induction periods of tumors.

Zusammenfassung

Die im Titel genannten Verbindungen wurden hinsichtlich ihrer carcinogenen Wirkungen bei der Ratte geprüft. Alle fünf untersuchten Verbindungen erwiesen sich dabei als Carcinogene, die vor allem hinsichtlich ihrer Organotropie und der Induktionszeit interessante Unterschiede aufweisen.

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Authors and Affiliations

  1. Institut für Toxikologie und Chemotherapie am Deutschen Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg

    M. Wiessler & D. Schmähl

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  1. M. Wiessler
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  2. D. Schmähl
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Wiessler, M., Schmähl, D. Zur carcinogenen Wirkung von N-Nitroso-Verbindungen. Z. Krebsforsch. 88, 25–31 (1976). https://doi.org/10.1007/BF00284744

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  • DOI: https://doi.org/10.1007/BF00284744

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