Abstract
Lead acetate (0.05 and 0.1 %) was given in drinking water to albine rats (120 to 150 g) of both sexes with the matched controls receiving Pb-free water. Audio-visual training was imparted to experimental animals in respect of conditioned avoidance response (CAR) and unconditioned response (UAR) in a Cook's apparatus and Techno-Y-maze. The group which received Pb simultaneously with training exhibited significant blockage in auditory based learning and performance. The group that received Pb 30 days before training showed defects in learning and performance.
Similar content being viewed by others
References
Aub, J. C., Fairhall, L. T., Minot, A. S., and Reznikoff, L.: 1926,Med. Mongr. 7, 1.
Bhattacharya, S. K., Kishore, K., Saxena, P. N., and Bhargava, K. P.: 1964,Arch. Int. Pharmacodyn. 150, 295.
Bullock, J. D., Wey, R. J., Zaia, J. A., Zarenbok, I., and Schooeder, H. A.: 1966,Arch. Env. Hlth. 13, 21.
Bushnell, P. J. and Bowman, R. E.: 1979,J. Toxicol. Env. Hlth. 5, 1015.
Cantarow, A. and Trumper, M.: 1944,Lead Poisoning, Williams and Wilkins, Baltimore, 1–264.
Carsons, T. L., Vangelder, G. A., Keras, G. C., and Buck, W. B.: 1974,Arch. Env. Hlth. 29, 154.
Cook, L. and Weidley, E.: 1956,Ann. N. Y. Acad. Sci. 66, 740.
Govoni, S., Montefusco, O., Spano, P. F., and Trabucchi, M.: 1978,Tox. Let. 2, 333.
Grandjean, P.: 1978,Env. Res. 17, 303.
Gusev, M. T.: 1960, in V. A. Ryazanov (ed.),Maximum Permissible Concentrations of Atmospheric Pollutants, Book 4, Washington, D.C., U.S. Dept. Com. Tech. Sci. Bul.
Kostas, J., McFarland, D. J., and Drew, W. G.: 1976,Pharmacology 14, 435.
Kim, C., Choi, H., Kin, C. C., Kin, J. K., Kim, M. S., Park, M. J., and Ahn, B. T.: 1975,Electroencephalog. Clin. Neurophysiol. 38, 235.
Landrigan, P. J., Baloh, R. H., Barthel, W. F., Whitworth, R. H., Stachling, N. W., and Rosenbhom, B. F.: 1975,Lancet 1, 708.
Lillis, R., Fischbein, A., Diamonds, S., Anderson, H. A., Selikoff, I. J., Blumberg, W. E., and Eisinger, J.: 1977,Arch. Env. Hlth. 32, 256.
Meltins, R. B. and Jenkins, C. D.: 1955,J. Amer. Med. Ass. 158, 15.
Milner, B.: 1965,Neuropsychologia 3, 317.
Pueschal, S. M.: 1974,Env. Hlth. Perspect. 7, 13.
Repko, J. D. and Corum, C. R. L.: 1976, Critical Review and Evaluation of the Neurological and Behavioural Sequelae of Inorganic Lead Absorption, ITR-74–26 (Tech. Rep.) Univ. Louisville, Ky.
Ronald, E. L. and Talbott, E. E.: 1978,Arch. Env. Hlth. 33, 236.
Satija, N. K., Seth, T. D., and Tandon, D. S.: 1977,Proc. Int. Sym. Industr., Toxicol. 757.
Sibergeld, E. K. and Goldberg, A. M.: 1975,Neuropharmacology 14, 431.
Singh, N., Donovan, C. M., and Hanshaw, J. B.: 1978,J. Pediat. 93, 1019.
Srimal, R. C., Singh, H. K., and Dhawan, B. N.: 1970,Arch. Int. Pharmacodyn. 188, 320.
Valciukas, J. A., Lillis, R., Fischbein, A., Selikoff, J. J., Eisinger, J., and Blumberg, W. E.: 1978,Science 201, 465.
Venkatakrishna-Bhatt, H.: 1984,J. Gen. Psychol. (in press).
Weir, P. A. and Hine, C. H.: 1970,Arch. Env. Hlth. 20, 45.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Venkatakrishna-Bhatt, H. Influence of oral lead acetate on cognitive functions and learning in rats. Water Air Soil Pollut 23, 375–380 (1984). https://doi.org/10.1007/BF00284733
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00284733