Summary
Four-hundred and ninety individuals belonging to the Vysya caste from Andhra Pradesh were screened for pseudocholinesterase variants at the E1 and E2 locus. A high incidence of the silent allele (gene frequency = 0.1112) was recorded with homozygotes exceeding 2% of the population. Dibucaine- and fluoride-resistant alleles were found in a heterozygous form with the usual alleles in four individuals each. No C5+ variant at the E2 locus was found.
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Altland, K., Goedde, H. W.: Heterogeneity in the silent gene phenotype of pseudocholinesterase of human serum. Biochem. Genet. 4, 321–338 (1970)
Ashton, G. C., Simpson, N. E.: C5 types of serum cholinesterase in a Brazilian population. Am. J. Hum. Genet. 18, 438–477 (1966)
Giblett, E. R.: Genetic markers in human blood. Oxford and Edinburgh: Blackwell 1969
Goedde, H. W., Benkmann, H. G., Singh, S., Das, B. M., Chakravarti, M. R., Delbruck, H., Flatz, G.: Genetic survey in the population of Assam. II. Serum protein and erythrocyte enzyme polymorphisms. Hum. Hered. 22, 331–337 (1972)
Gutsche, B. B., Scott, E. M., Wright, R. C.: Hereditary deficiency of pseudocholinesterase in Eskimos. Nature 215, 322–323 (1967)
Harris, H., Whittaker, M.: Differential inhibition of human serum cholinesterase with flouride: Recognition of two new phenotypes. Nature 191, 496–498 (1961)
Hodgkin, W. E., Giblett, E. R., Levine, H., Bauer, W., Motulsky, A. G.: Complete pseudocholinesterase deficiency: Genetic and immunological characterization. J. Clin. Invest. 44, 486–493 (1965)
Kalow, W., Genest, K.: A method for the detection of atypical forms of human serum cholinesterase. Determination of dibucaine members. Can. J. Biochem. 35, 339–346 (1957)
Scott, E. M., Weaver, D. D., Wright, R. C.: Discrimination of phenotypes in human serum cholinesterase deficiency. Am. J. Hum. Genet. 22, 363–369 (1970)
Scott, E. M.: Inheritance of two types of deficiency of human serum cholinesterase. Ann. Hum. Genet. 37, 139–143 (1973)
Singh, S., Amma, M. K. P., Sareen, K. N., Goedde, H. W.: A study of pseudocholinesterase polymorphism among a Punjabi population. Hum. Hered. 21, 388–393 (1971)
Steegmüller, H.: On the geographical distribution of pseudocholinesterase variants. Hum. Genet. 26, 167–185 (1975)
Szeinberg, A., Pipano, S., Assa, M., Medalie, J. H., Neufeld, H. N.: High frequency of atypical pseudocholinesterase gene among Iraqui and Iranian Jews. Clin. Genet. 3, 123–127 (1972)
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Rao, P.R., Gopalam, K.B. High incidence of the silent allele at cholinesterase locus I in Vysyas of Andhra Pradesh (S. India). Hum Genet 52, 139–141 (1979). https://doi.org/10.1007/BF00284608
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DOI: https://doi.org/10.1007/BF00284608