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Quantitative studies on the arrangment of human metaphase chromosomes

VII. The association pattern of acrocentric chromosomes in carriers of Robertsonian translocations and in their relatives with normal karyotypes

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Summary

The pattern of association of acrocentric chromosomes was examined in ten and five carriers of a 15/21 and a 13/14 Robertsonian translocation, respectively, and was compared with that of the same numbers of relatives with normal karyotypes. In the carriers of 15/21 translocation, the number of large associations (involving more than two acrocentrics) and the association frequencies for individual acrocentric chromosomes, were significantly higher than in the control group. The mean number of associations of the single homologs of the translocation chromosomes was much higher than that of the other acrocentrics. In the carriers of 13/14 translocations, only the association frequency for chromosome 13 was higher than in the normal relatives. The uninvolved chromosomes homologous to those involved in translocations showed an insignificant increase in associations in comparison with the other acrocentrics. These results suggest that some mechanism within the cells compensates for the effect of missing acrocentrics or of acrocentrics lacking NORs on the number of associations. The possible relations of this phenomenon to the activity of the nucleolus organizing regions are discussed.

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References

  • Bloom, S. E., Goodpasture, C.: An improved technique for selective silver staining of nucleolar organizer regions in human chromosomes. Hum. Genet. 34, 199–206 (1976)

    Google Scholar 

  • de Capoa, S., Ferraro, M., Memendez, F., et al.: Ag staining of the nucleolus organizer (NO) and its relationship to satellite association. Hum. Genet. 44, 71–78 (1978)

    Google Scholar 

  • Hansson, A.: Compensatory mechanism in the satellite association patterns of individuals with Robertsonian translocations. Hereditas 81, 101–112 (1975)

    Google Scholar 

  • Hayata, I., Oshimura, M., Sandberg, A. A.: N-band polymorphism of human acrocentric chromosomes. Hum. Genet. 36, 55–61 (1977)

    Google Scholar 

  • Howell, W. M., Denton, T. E., Diamond, J. R.: Differential staining of satellite regions of human acrocentric chromosomes. Experientia 31, 260 (1975)

    Google Scholar 

  • Luchsinger, U., Bühler, E., Mehes, K., Stalder, G.: Satellitenassoziationen bei autosomalen und gonosomalen Chromosomenanomalien und bei Hypothyreosen. Humangenetik 8, 53–61 (1969)

    Google Scholar 

  • Miller, D. J., Miller, D. A., Dev, V. G., Tantravahi, R., Croce, C. M.: Expression of human and suppression of mouse nucleolus organizer activity in mouse-human somatic cell hybrids. Proc. Natl. Acad. Sci. USA 73, 4531–4535 (1976)

    Google Scholar 

  • Miller, D. A., Tantravahi, R., Dev, V. G., Miller, O. J.: Frequency of satellite associations of human chromosomes is correlated with the amount of Ag-staining of the nucleolus organizing region. Am. J. Hum. Genet. 29, 480–502 (1978)

    Google Scholar 

  • Ohno, S., Trujillo, J. M., Kaplan, W. D., Kinosita, R.: Nucleolus organizers in the causation of chromosomal anomalies in man. Lancet 1961 II, 123–126

    Google Scholar 

  • Rosenkranz, W., Fleck, S.: Die Bedeutung der Assoziation satellitentragender Chromosomen. Humangenetik 7, 9–21 (1969)

    Google Scholar 

  • Rosenkranz, W., Holzer, S.: Satellite association. A possible cause of chromosomal aberrations. Humangenetik 16, 147–150 (1972)

    Google Scholar 

  • Zang, K. D., Back, E.: Quantitative studies on the arrangement of human metaphase chromosomes. I. Individual features in the association pattern of acrocentric chromosomes of normal males and females. Cytogenetics 7, 455–470 (1968)

    Google Scholar 

  • Zankl, H., Hahmann, S.: Cytogenetic examination of the NOR activity in a proband with 13/13 translocation and in her relatives. Hum. Genet. 43, 275–279 (1978)

    Google Scholar 

  • Zankl, H., Zang, K. D.: Quantitative studies on the arrangement of human metaphase chromosomes. V. The association pattern of acrocentric chromosomes in human meningiomas after the loss of G and D chromosomes. Hum. Genet. 40, 149–157 (1978)

    Google Scholar 

  • Zankl, H., Michaelsen, H., Zang, K. D.: Quantitative studies on the arrangement of human metaphase chromosomes. VI. The association pattern of acrocentric chromosomes in patients with trisomy 13. Hum. Genet. 49, 185–189 (1979)

    Google Scholar 

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Authors and Affiliations

  1. Institute of Human Genetics, University of Saarland, D-6650, Homburg/Saar, Federal Republic of Germany

    H. Zankl & K. D. Zang

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  1. H. Zankl
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  2. K. D. Zang
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Zankl, H., Zang, K.D. Quantitative studies on the arrangment of human metaphase chromosomes. Hum Genet 52, 119–125 (1979). https://doi.org/10.1007/BF00284605

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