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Simultaneous tumors in the respiratory system and urinary bladder of syrian golden hamsters

Die gleichzeitige Entstehung von Tumoren im Respirationssystem und in der Harnblase beim Syrischen Goldhamster

Zeitschrift für Krebsforschung und Klinische Onkologie volume 82, pages 153–158 (1974)Cite this article

Summary

The hamster was used as a model for systematic studies in primary multiple carcinogenesis induced by DBN. After subcutaneous and intragastric treatment, neoplasms were simultaneously found in the respiratory system and in the urinary bladder. A dose dependent effect was seen for survival, tumor incidence and latency. Papillomas and epidermoid carcinomas were found in the nasal cavities; papillary polyps were mainly found in the larynx, trachea and stem bronchi whereas mixed and combined carcinomas were observed in the lungs. The urinary bladder showed transitional cell papillomas and carcinomas.

Zusammenfassung

Die primär multiple Carcinogenese durch DBN wurde systematisch am Modell des Goldhamsters untersucht. Nach subcutaner wie auch nach intragastrischer Gabe fanden sich gleichzeitig Tumoren in Respirationssystem und in der Harnblase. Überlebenszeit, Tumorhäufigkeit und Latenzzeit waren abhängig von der Dosis. Papillome und Plattenepithelcarcinome zeigten sich in den Nasenhöhlen; papilläre Polypen wurden meist in Larynx, Trachea und Stammbrochien beobachtet, in den Lungen fanden sich gemischte und kombinierte Carcinome. Die Harnblase zeigte Übergangsepithelpapillome und -Carcinome.

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References

  • Althoff,J., Cardesa,A., Pour,P., Mohr,U.: Carcinogenic effect of N-nitrosohexamethyleneimine in Syrian golden hamsters. J. nat. Cancer Inst. 50, 323–329 (1973)

    Google Scholar 

  • Althoff,J., Krüger,F.W., Mohr,U., Schmähl,D.: Dibutylnitrosamine carcinogenesis in Syrian golden and Chinese hamsters. Proc. Soc. exp. Biol. 136, 168–173 (1971)

    Google Scholar 

  • Althoff,J., Mohr,U., Page,N.: The carcinogenic effect of dibutylnitrosamine in European hamsters. J. nat. Cancer Inst. (1974 in press)

  • Althoff,J., Pour,P., Cardesa,A., Mohr,U.: Comparative studies of the neoplastic response to a single dose of nitroso compounds. 2. The effect of N-dibutylnitrosamine in the Syrian golden hamster. Z. Krebsforsch. 79, 85–89 (1973)

    Google Scholar 

  • Anthony,H.M., Thomas,G.M.: Bladder tumors and smoking. Int. J. Cancer 5, 266–272 (1970)

    Google Scholar 

  • Bauer,K.H.: Das Krebsproblem. Berlin-Göttingen-Heidelberg: Springer-Verlag 1963

    Google Scholar 

  • Bertram,J.S., Craig,A.W.: Induction of bladder tumours in mice with dibutylnitrosamine. Brit. J. Cancer 24, 352–359 (1970)

    Google Scholar 

  • Cole,P., Monson,R.R., Haning,H., Friedell,G.H.: Smoking and cancer of the lower urinary tract. New Engl. J. Med. 284, 129–134 (1971)

    Google Scholar 

  • Dontenwill,W., Mohr,U.: Über Tracheal- und Bronchialcarcinome bei Goldhamstern nach Behandlung mit Diäthylnitrosamin. Klin. Wschr. 39, 493 (1961a)

    Google Scholar 

  • Dontenwill,W.: Carcinome des Respirationstractus nach Behandlung von Goldhamstern mit Diäthylnitrosamin. Z. Krebsforsch. 64, 305–312 (1961b)

    Google Scholar 

  • Dontenwill,W.: Die organotrope Wirkung der Nitrosamine. Z. Krebsforsch 65, 166–167 (1962)

    Google Scholar 

  • Druckrey,H., Preussmann,R., Ivankovic,S., Schmähl,D.: Organotrope carcinogene Wirkungen bei 65 verschiedenen N-nitroso-Verbindungen an BD-Ratten. Z. Krebsforsch. 69, 103–201 (1967)

    Google Scholar 

  • Druckrey,H., Schmidt,C.H., Mennel,H.D., Stahl,K.W.: Selective Erzeugung von Blasenkrebs an Ratten durch Dibutyl- und N-Butyl-N-butanol-(4)-nitrosamin. Z. Krebsforsch. 66, 280–290 (1964)

    Google Scholar 

  • Gross,E.: Berufskrebs. Deutsche Forschungsgemeinschaft, Bad Godesberg (1967)

  • Herrold,K.: Upper respiratory tract tumors induced in Syrian hamsters by N-methyl-N-nitrosourea. Int. J. Cancer 6, 217–222 (1970)

    Google Scholar 

  • Ivankovic,S., Bücheier,J.: Leber- und Blasencarcinome beim Meerschweinchen nach Di-n-butylnitrosamin. Z. Krebsforsch. 71, 183–185 (1968)

    Google Scholar 

  • Kreyberg,L.: Histological typing of lung tumors. WHO, Geneva (1967)

    Google Scholar 

  • Lijinsky,W., Ferrero,A., Montesano,R., Wenyon,C.E.M.: Tumorigenicity of cyclic nitrosamines in Syrian golden hamsters. Z. Krebsforsch. 74, 185–189 (1970)

    Google Scholar 

  • Mohr, U.: Effects of diethylnitrosamine in the respiratory system of Syrian golden hamsters. Morphology of respiratory carcinogenesis. In: 21. USAEC Symposium 255–265 (1970)

  • Mohr,U., Althoff,J.: Carcinogenic activity of aliphatic nitrosamines via the mother's milk in the offspring of Syrian golden hamsters. Proc. Soc. exp. Biol. 136, 1007–1009 (1971)

    Google Scholar 

  • Odashima,S.: Development of leukemia in rats by oral administration of N-nitrosobutylurea in the drinking water. Gann 60, 237 (1969)

    Google Scholar 

  • Okada,M., Suzuki,E.: Metabolism of butyl-(4-hydroxybutyl)-nitrosamine in rats. Gann 63, 391–392 (1972)

    Google Scholar 

  • Turusov, W.: Tentative classification of respiratory tract tumors in laboratory animals. Morphology of respiratory carcinogenesis. In: 21. USAEC Symposium 457–472 (1970)

  • Varga,G., Kovacs,G., Kertes,J.: The simultaneous occurrence of four primary malignant tumors. J. Path. 105, 57–61 (1971)

    Google Scholar 

  • Wood,M., Flaks,A., Clayson,D.B.: The carcinogenic activity of dibutylnitrosamine in JFxC57 mice. Eur. J. Cancer 6, 433–440 (1970)

    Google Scholar 

  • Wynder,E.L., Onderdonk,J., Mantel,N.: An epidemiological investigation of cancer of the bladder. Cancer 16, 1388–1407 (1963)

    Google Scholar 

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Affiliations

  1. Abteilung für Experimentelle Pathologie, Medizinische Hochschule Hannover, Hannover

    J. Althoff

  2. Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 42nd and Dewey Avenue, 68105, Omaha, Nebraska, USA

    J. Althoff

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  1. J. Althoff
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Althoff, J. Simultaneous tumors in the respiratory system and urinary bladder of syrian golden hamsters. Z. Krebsforsch. 82, 153–158 (1974). https://doi.org/10.1007/BF00284500

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  • DOI: https://doi.org/10.1007/BF00284500

Keywords

  • Carcinoma
  • Urinary Bladder
  • Nasal Cavity
  • Respiratory System
  • Papilloma