Summary
The binding of Ca2+ to phospholipids from various experimental tumors has been studied. The experimental results indicate that the phosphatidylserine is the main Ca2+ binding substance.
In most of the isolated phospholipids a phospholipid-calcium-phosphate complex seems to be present. The presence of orthophosphate considerably enhances the Ca2+ — binding to the tumor phospholipids. The increase of Ca2+ concentration also augments this binding. The possible implications of this behavior for the cell membrane permeability are discussed.
Zusammenfassung
Es wurden an verschiedenen, künstlich erzeugten, Tumoren die mit Phosphorlipoiden gebildeten Ca2+—Verbindungen untersucht.
Die Versuchsergebnisse lassen als wichtigste Ca2+—Verbindung das „Phosphatidylserin“ erkennen. In den meisten der isolierten Phosphorlipoide scheint ein Komplex von Phosphorlipoid-Calciumphosphat vorzuliegen.
Die Anwesenheit von Orthophosphat verstärkt die Ca2+-Bindung an den Tumor-Phosphorlipoiden erheblich. Auch erhöhte Ca2+-Konzentration beeinflußt die Bindung positiv.
Die mögliche Bedeutung dieses Verhaltens auf die Durchlässigkeit der Zellmembrane steht zur Diskussion.
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Diese Arbeit wurde mit Unterstützung des Ministeriums für Wissenschaft u. Forschung des Landes Nordrh.-Westfalen durchgeführt.
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Anghileri, L.J. Calcium binding to phospholipids from experimental tumors. Z. Krebsforsch. 78, 337–344 (1972). https://doi.org/10.1007/BF00284347
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DOI: https://doi.org/10.1007/BF00284347