Summary
The carcinogenic effect of dimethylnitrosamine (DMN) injected subcutaneously in Syrian golden hamsters as well as the synergistic effect of intratracheal instillations of ferric oxide were studied. DMN alone induced cavernous hemangiomas, hemangioendotheliomas, hemangioendotheliosarcomas, as well as one hepatoma of the liver and one papilloma of the forestomach, but no tumors of the respiratory system. When ferric oxide was given in addition to DMN, liver tumors of vascular and biliary origin were seen, in addition to tumors of the nasal cavity, neuroepithelial tumors and one adenoma. It was concluded that subcutaneously injected DMN is a powerful hepatic carcinogen for the Syrian golden hamster, producing liver tumors of vascular, bile duct as well as liver cell origin. The lack of tumorigenic effect in the respiratory system was considered to be due to the lack of metabolism of DMN in the lung.
Zusammenfassung
Die carcinogene Wirkung von subkutan injiziertem Dimethyl-Nitrosamin (DMN) beim syrischen Goldhamster sowie der synergistische Effekt von intratrachealer Instillation von Eisenoxyd wurde untersucht. DMN allein verursachte cavernöse Haemangiome, Haemangioendotheliome, Haemangioendotheliosarkome sowie ein Hepatom in der Leber und ein Papillom des Magens, aber keine Tumoren des Atmungstraktes. Wenn Eisenoxyd zusätzlich zu DMN gegeben wurde, konnten Lebertumoren vaskulären und biliären Ursprungs gefunden werden, aber auch noch Tumoren der Nasenhöhle, neuroepitheliale Tumoren und ein Adenom. Daraus wird geschlossen, daß subkutan injiziertes DMN ein sehr wirksames Carcinogen für den syrischen Goldhamster darstellt, das Lebertumoren vaskulären, biliären und hepatozellulären Baues erzeugt. Das Fehlen der cancerogenen Wirkung im Atmungstrakt wird auf das Fehlen eines Metabolismus des DMN in der Lunge zurückgeführt.
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Supported by N. I. H. Contract PH 43-68-959
Parts of the work reported in this paper were undertaken during the tenure of a Research Training Fellowship awarded by the International Agency for Research on Cancer.
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Stenback, F., Ferrero, A., Montesano, R. et al. Synergistic effect of ferric oxide on dimethylnitrosamine carcinogenesis in the Syrian golden hamster. Z. Krebsforsch. 79, 31–38 (1973). https://doi.org/10.1007/BF00284337
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DOI: https://doi.org/10.1007/BF00284337