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Occurrence of volatile N-nitrosamines in animal diets

Vorkommen flüchtiger N-Nitrosamin im Versuchstierfutter

Summary

46 samples of commercially available diets for experimental animals have been analysed for their content of volatile N-nitrosamines by use of a nitrosamine-specific detection method (TEA-detector). 80% of all analysed samples were positive for N-nitrosodimethylamine with a maximum content of 79 ppb (μg/kg) found in one sample. 59% of the samples were positive for N-nitrosopyrrolidine with 26 ppb as highest content. In 3 samples trace quantities (<1 ppb) of N-nitrosodiethylamine were found, one sample contained N-nitrosopiperidine (4 ppb).

Zusammenfassung

46 Proben kommerziell erhältlicher Futtermittel für Versuchstiere wurden mittels eines Nitrosamin-spezifischen (TEA) Detektors auf den Gehalt an flüchtigen Nitrosaminen untersucht. 80% aller untersuchten Proben enthielten N-Nitrosodimethylamin, der höchste gefundene Wert lag bei 79 ppb (μg/kg). 59% der Proben enthielten N-Nitrosopyrrolidin mit einem Maximalwert von 26 ppb in einer Probe. Drei Proben enthielten Spuren (<1 ppb) von N-Nitrosodiäthylamin, eine N-Nitrosopiperidin (4 ppb).

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Guest scientist from the Tallin Polytechnical Institute, Tallinn, USSR

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Kann, J., Spiegelhalder, B., Eisenbrand, G. et al. Occurrence of volatile N-nitrosamines in animal diets. Z. Krebsforsch. 90, 321–323 (1977). https://doi.org/10.1007/BF00284306

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  • DOI: https://doi.org/10.1007/BF00284306

Keywords

  • Public Health
  • Cancer Research
  • Experimental Animal
  • Detection Method
  • Trace Quantity