Summary
49 patients with disseminated bronchogenic carcinoma (small cell, 16; squamous cell, 17; large cell, 12; adeno, 4) were treated with a combination of adriamycin, cyclophosphamide, vincristine and DTIC. In a randomized series (21 patients) chemotherapy alone was compared to chemotherapy plus heparin. Partial remission was achieved in 8 patients with small cell carcinoma, in 5 patients with large cell carcinoma and in 2 patients with squamous cell carcinoma. The survival of patients who responded to therapy was greater than the survival of patients who did not respond to therapy. The duration of remission and the survival time was not longer in patients who had additional heparin therapy.
Zusammenfassung
49 Patienten mit metastasiertem Bronchialcarcinom (16 kleinzellige Carcinome, 17 Plattenepithelcarcinome, 12 großzellige Carcinome, 4 Adenocarcinome) wurden mit einer Kombinationschemotherapie bestehend aus Adraimycin, Cyclophosphamid, Vincristin und DTIC behandelt. Zusätzlich erhielten in einer Pilot-Studie 21 Patienten nach Randomisierung eine Anticoagulantientherapie mit Heparin oder wurden nicht anticoaguliert. Bei 8 Patienten mit kleinzelligem Carcinom, 5 Patienten mit großzelligem Carcinom und 2 Patienten mit Plattenepithelcarcinom konnte eine Teilremission erzielt werden. Eine weitere Anzahl von Patienten zeigte ein stationäres Tumorwachstum über mehrere Monate. Die mittleren Überlebenszeiten waren bei Patienten, die auf die Therapie ansprachen, deutlich länger als bei Therapieversagern. Ein zusätzlicher günstiger Effekt der Anticoagulantientherapie wurde nicht gesehen.
Similar content being viewed by others
Literatur
Agostino,D., Clifton,E.E., Girolami,A.: Effect of prolonged coumadin treatment on the production of pulmonary metastases in the rat. Cancer 19, 284–288 (1966).
Alberto,P., Brunner,K., Martz,G., Obrecht,J.P., Sonntag,R.W.: Treatment of bronchogenic carcinoma with simultaneous or sequential combination chemotherapy, including methotrexate, cyclophosphamide, procarbazine, and vincristine. Cancer 38, 2208–2216 (1976).
Alth,G., Denck,H., Fischer,M. et al.: Aspects of the immunologic treatment of lung cancer. Cancer Chemother. Rep. 4, 271–274 (1973)
Bodey,G.P., Lagakos,S.W., Gutierrez,A.C., Wilson,H.E., Selawry,O.S.: Therapy of advanced squamous carcinoma of the lung. Cyclophosphamide versus “COMB”. Cancer 39, 1026–1031 (1977)
Brown,J.M.: A study of the mechanism by which anticoagulation with warfarin inhibits blood-borne metastases. Cancer Res. 33, 1217–1224 (1973)
Edmonson,J., Lagakos,S.: Combination chemotherapy for metastatic lung cancer. Proc. Am. Ass. Cancer Res. 15, 180 (1974)
Edmonson,J.M., Stolbach,L., Mittelmann,A., Lagakos,S.W.: Combination chemotherapy for metastatic lung cancer. Proceedings XI International Cancer Congress, Florence, 1974, p. 591
Elias,E.G., Shukla,S.K., Mink,J.B.: Heparin and chemotherapy in the management of inoperable lung carcinoma. Cancer 36, 129–136 (1975)
Gottlieb,J.A., Bodey,G.P., Sinkovics,J.G., Rodriguez,V., Burgess,M.A.: An effective new 4-drug combination regimen (Cy-Va-DIC) for metastatic sarcomas. Proc. Am. Assoc. Cancer Res. Am. Soc. Clin. Oncol. 15, 162, March 1974, Abstract No. 713
Green,R., Humphrey,E., et al.: Alkylating agents in bronchogenic carcinoma. Am. J. Med. 46, 516–525 (1969)
Hansen,H.H., Muggia,F.M., Andrews,R., Selawry,O.S.: Intensive combined chemotherapy and radiotherapy in patients with non-resectable bronchogenic carcinoma. Cancer 30, 315 (1972)
Hansen,H.H., Selawry,O.S., Simon,R.S. et al.: Combination chemotherapy of advanced lung cancer. Cancer 38, 2201–2207 (1976)
Hornback,N.B., Einhorn,L., Shidnia,H., Joe,B.T., Krause,M., Furnas,B.: Oat cell carcinoma of the lung. Early treatment results of combination radiation therapy and chemotherapy. Cancer 37, 2658–2664 (1976)
Israel,L., Edelstein,R.L.: Non-specific immunostimulation with corynebacterium parvum in human cancer. Immunological aspects of neoplasia. Edts.: M. Anderson Baltimore: Williams and Wilkins 1974
Livingston,R.B., Fee,W.H., Einhorn,L.H., Burgess,M.A., Freireich,E.J., Gottlieb,J.A., Farber,M.O.: BACON (bleomycin, adriamycin, CCNU, oncovin and nitrogen mustard) in squamous lung cancer. Cancer 37, 1237–1242 (1976)
Nixon,D.W., Carey,R.W., Suit,H.D., Aisenberg,A.C: Combination chemotherapy in oat cell carcinoma of the lung. Cancer 36, 867–872 (1975)
Pines,A.: A 5-year controlled study of B.C.G. and radiotherapy for inoperable lung cancer. Lancet 1976 I, 380–381
Seeber,S., Schmidt,C.G., Holfeld,H., Scherer,E.: Integrale Behandlung (Chemoand Radiotherapy) des inoperablen Bronchialcarcinoms. Dtsch. med. Wschr. 102, 147–152 (1977)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gropp, C., Havemann, K., Gassel, W.D. et al. Kombinationschemotherapie bei Patienten mit metastasiertem Bronchialcarcinom. Z. Krebsforsch. 90, 301–306 (1977). https://doi.org/10.1007/BF00284303
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00284303