Summary
The purpose of this study was to find whether gastric resection enhances the incidence of carcinoma in the remaining part of the stomach. 66 male Wistar rats were subjected to stomach resection according to the Billroth I or the Billroth II method. These rats, as well as control animals with intact stomachs, were fed the carcinogen N-Methyl-N′-nitro-N-nitrosoguanidine (NG). — 25 of 66 animals developed carcinomas in the gastric remnant. Precancerous lesions were seen in 18 rats. The tumours were characterized histologically as adenocarcinomas. They were almost exclusively localized in the region of the gastroenteral anastomosis. The process of tumour formation in the resected stomach was completed within 17–31 weeks on continous administration of NG in a concentration of 120 mg/l in the drinking water. In contrast to these findings, the development of cancer in the intact stomach required on average 41 weeks under the same conditions of NG administration. However, with regard to the incidence of malignant changes, no significant difference was observed between animals undergoing the Billroth I method and those undergoing the Billroth II method.—The results suggest that the resected stomach of the rat is more susceptible to induction of cancer than the intact one. Exposure of the resected stomach to an oral carcinogen induces carcinogenesis predominantly in the anastomotic region.
Zusammenfassung
Die Induktion von Carcinomen im resezierten Magen der Ratte wurde untersucht. Dabei sollte die Frage geprüft werden, ob der operative Eingriff zur Krebsbildung im Magenstumpf disponiert. 66 männliche Wistarratten wurden nach Billroth I oder Billroth II magenreseziert. 5 Wochen nach Resektion erhielten die Versuchstiere N-Methyl-N′-Nitro-N-Nitrosoguanidin (NG) in einer Konzentration von 120 mg/1 im Trinkwasser. 17–31 Wochen nach kontinuierlicher Verabreichung von NG wurden Tumoren im Magenstumpf beobachtet. 25 von insgesamt 66 resezierten Ratten wiesen histologisch Carcinome auf, 18 weitere zeigten präcanceröse Veränderungen. Im Hinblick auf die Carcinomhäufigkeit bestehen keine Unterschiede zwischen Magenresektion nach Billroth I und Magenresektion nach Billroth II. Im Gegensatz hierzu wurden Magencarcinome bei 44 nicht resezierten Ratten erst nach 41 Wochen beobachtet.
Die Versuchsergebnisse legen den Schluß nahe, daß der resezierte Magen der Ratte für die Induktion von Carcinomen empfindlicher ist als das nicht resezierte Organ.
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This study was supported by a grant from the Deutsche Forschungsgemeinschaft.
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Dahm, K., Werner, B. Susceptibility of the resected stomach to experimental carcinogenesis. Z. Krebsforsch. 85, 219–229 (1976). https://doi.org/10.1007/BF00284082
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DOI: https://doi.org/10.1007/BF00284082