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Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters

Transplacentare Effekte der Äthylnitrosoharnstoff-Vorstufen, Äthylharnstoff und Natriumnitrit beim Hamster

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Summary

Four simultaneous dosages of the ethylnitrosourea precursors, ethylurea and sodium nitrite, were administered intragastrically to pregnant hamsters at 100 mg/kg and 50 mg/kg respectively, from the 12–15th days of pregnancy. The treatment induced multiple neurogenic tumors of the peripheral nervous system in the offspring.

Female progeny developed a greater incidence and multiplicity of peripheral nervous system tumors with significantly shorter latencies than males, thus establishing evidence that the tumors were age and sex dependent. The tumors presented varied morphological patterns and upon transplantation, grew regularly, exhibiting their malignant nature. The possible influence of estrogenic hormones on the development and growth of peripheral nervous system tumors and comparative aspects of the relationship between prenatal and postnatal carcinogenesis with regard to the ensuing tumor spectra as a consequence of exposure to the same chemical agent, are discussed.

Zusammenfassung

Vorstufen von Äthylnitrosoharnstoff, nämlich Äthylharnstoff (100 mg/kg K.G.) und Natriumnitrit (50 mg/kg K.wG.), wurden simultan trächtigen Syrischen Goldhamstern täglich vom 12. bis 15.Tag der Tragzeit intragastrisch verabreicht. Bei den Nachkommen fanden sich Neoplasmen des peripheren Nervensystems. Häufigkeit und Multiplizität dieser Tumoren waren bei weiblichen Jungen erhöht, gleichzeitig war die Latenzzeit verkürzt. Die Tumoren deuten auf eine Alters-und Geschlechtsabhängigkeit bei der Tumorentstehung hin. Die Morphologie der Neoplasmen war unterschiedlich. Die Malignität wurde durch regelmäßige Transplantation belegt. Der mögliche Einfluß von Geschlechtshormonen auf die Entwicklung und das Wachstum dieser Tumoren des peripheren Nervensystems wurde diskutiert. Dabei wurden auch Beziehungen zwischen pränataler und postnataler chemischer Carcinogenese unter Berücksichtigung des Tumorspektrums verglichen.

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Authors and Affiliations

  1. The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 68105, Omaha, Nebraska

    M. Rustia

  2. The Nebraska Methodist Hospital and the Department of Pathology, University of Nebraska Medical Center, 68105, Omaha, Nebraska

    J. Schenken

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  1. M. Rustia
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  2. J. Schenken
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Supported by Public Health Service Contracts-Nos. 43-68-959 and 1 CP33278 from the National Cancer Institute.

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Rustia, M., Schenken, J. Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters. Z. Krebsforsch. 85, 201–217 (1976). https://doi.org/10.1007/BF00284081

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  • DOI: https://doi.org/10.1007/BF00284081

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