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A linkage group with FRA16B (the fragile site at 16q22.1)

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Summary

Polymorphic DNA markers located in bands 16q13, 16q21 and 16q22 were examined for recombination with FRA16B, the fragile site at 16q22.100. A tight linkage cluster D16S10-FRA16B-D16S4-HP was established. There were no recombinants \({\text{(}}\hat \theta = {\text{0}}{\text{.0, }}{\mathbf{\hat z}}{\text{ = 8}}{\text{.3)}}\) between D16S10 and D16S4, which flank FRA16B. The markers D16S10 and D16S4 are in close proximity on the genetic map and delineate a small chromosomal segment, which contains the distamycin A-inducible fragile site.

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Authors and Affiliations

  1. Cytogenetics Unit, Department of Histopathology, Adelaide Children's Hospital, 5006, North Adelaide, S.A., Australia

    J. C. Mulley, V. J. Hyland, A. Fratini, L. J. Bates, A. K. Gedeon & G. R. Sutherland

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  1. J. C. Mulley
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  2. V. J. Hyland
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  3. A. Fratini
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  4. L. J. Bates
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  5. A. K. Gedeon
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  6. G. R. Sutherland
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Mulley, J.C., Hyland, V.J., Fratini, A. et al. A linkage group with FRA16B (the fragile site at 16q22.1). Hum Genet 82, 131–133 (1989). https://doi.org/10.1007/BF00284044

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  • DOI: https://doi.org/10.1007/BF00284044

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