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Comparative studies of neoplastic response to a single dose of nitroso compounds

5. The effect of dimethylnkrosamine in swiss, ASW/SN and a-strain mice

Vergleichende Studien hinsichtlich der carcinogenen Wirkung nach einmaliger Applikation von Nitrosoverbindungen

5. Die Wirkung von Dimethylnitrosamin bei Swiss, ASW/SN und A-Mäusen

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Summary

The tumorigenic effect of dimethylnitrosamine given once at 5 different dose levels was compared in adult Swiss, ASW/SN and A-strain mice. Considering the overall tumour incidence, at the highest dose level an increase was found in Swiss and ASW/SN mice, but not in A-strain animals. However, the effect of treatment was unequivocal for lung neoplasms. The rate of carcinomas rose significantly in all 3 strains, although a clear dose response-relationship could be established only in Swiss and ASW/SN mice. A dose-dependent effect for adenomas was found solely in Swiss mice.

Zusammenfassung

Die tumorerzeugende Wirkung von Dimethylnitrosamin wurde nach einmaliger Gabe in 5 unterschiedlichen Dosen bei ausgewachsenen Swiss, ASW/SN-und A-Mäusen verglichen. Eine erhöhte Tumorhäufigkeit fand sich nur in der höchsten Dosierungsgruppe bei Swissund ASW/SNMäusen, jedoch nicht bei Tieren des A-Stammes. Die Wirkung der Behandlung war allerdings bei Lungentumoren eindeutig. Die Rate der Carcinome stieg signifikant in allen 3 Stämmen, obwohl eine klare Dosis-Wirkungsbeziehung nur bei Swissund ASW/SN-Mäusen gefunden wurde. Die Häufigkeit von Adenomen war nur bei Swiss-Mäusen dosisabhängig.

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Authors and Affiliations

  1. The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 42nd and Dewey Avenue, 68105, Omaha, Nebraska, USA

    Y. Ii, A. Cardesa, K. Patil, J. Althoff & P. Pour

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  1. Y. Ii
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  2. A. Cardesa
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  3. K. Patil
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  4. J. Althoff
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  5. P. Pour
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Supported by U.S. Public Health Service contract NO1 CP33278 from the National Cancer Institute, NIH.

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Ii, Y., Cardesa, A., Patil, K. et al. Comparative studies of neoplastic response to a single dose of nitroso compounds. Z. Krebsforsch. 86, 165–170 (1976). https://doi.org/10.1007/BF00284004

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  • DOI: https://doi.org/10.1007/BF00284004

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