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Ossification in cancer of the stomach

An experimental study

Verknöcherung bei Magenkrebs

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Summary

In rats with Nitrosoguanidine induced carcinomas of the gastric stump, heterotopic ossifications are found frequently. The following stages of differentiation during the desmal ossification in the stump carcinomas are demonstrated. 1. Osteoblasts, 2. Osteoid, 3. Woven bone, 4.Lamellar bone. — The islands of metaplastic bone cells are predominantly located in the invasive marginal zone of the carcinoma of the gastric stump. The histology of the heterotopic ossification in the gastric stump of the rat is similar to that one seen in stomach cancer of men. The model here described seems to be suitable for further study of metaplastic bone formation in the gastrointestinal tract.

Zusammenfassung

Heterotope Verknöcherungen treten im Nitrosoguanidininduzierten Magenstumpfcarcinom der Ratte gehäuft auf. Folgende Differenzierungsstufen der desmalen Knochenbildung wurden gefunden: 1. Osteoblasten, 2. Osteoid, 3. geflechtartiger Knochen, 4. lamellärer Knochen. Die metaplastischen Knocheninseln sind vorwiegend in der invasiven Randzone der Magenstumpfcarcinome lokalisiert. Da Analogien zur metaplastischen Knochenbildung im Magencarcinom des Menschen bestehen, eignet sich das hier beschriebene Modell zum Studium der heterotopen Ossifikation.

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Authors and Affiliations

  1. Abteilung für Allgemeinchirurgie und Abteilung für Mikroskopische Anatomie, Universität Hamburg, Martinistraße 52, D-2000, Hamburg 20, Germany

    B. Werner, K. Dahm & H. Breucker

Authors
  1. B. Werner
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  2. K. Dahm
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  3. H. Breucker
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Werner, B., Dahm, K. & Breucker, H. Ossification in cancer of the stomach. Z. Krebsforsch. 86, 147–154 (1976). https://doi.org/10.1007/BF00284002

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  • DOI: https://doi.org/10.1007/BF00284002

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