Resumé
Les tumeurs pulmonaires induites chez la souris swiss par le NMUR apparaissent essentiellement constituées de cellules apparentées aux pneumocytes granuleux (pneumocytes II ou B). D'autres cellules plus rares, de morphologie épithéliale bronchiolaire peuvent participer á la prolifération.
L'étude ultrastructurale des cellules tumorales suggère que leurs fonctions secrétoires sont perturbées.
Le mode de formation des structures cristallins intratumorales est discuté, ainsi que leur rapport éventuel avec la production du surfactant.
Les territoires péri-tumoraux sont caractérisés par une fibrose interstitielle dense où les fibres de collagène sont associées à uns substance élastoïde.
Summary
The pulmonary tumours induced in Swiss mice by NMUR seem to be constituted for the most part by cells closely related to the granular pneumocytes (pneumocytes II ou B). Other rarer cells, of epithelial bronchiolar aspect, may take part in the proliferation.
The ultrastructural study of tumoral cells suggest that their secretory functions are disturbed.
The origin of the crystalline intratumoral structures is discussed, as well as their possible relationship with the production of surfactant.
The peritumoral areas are characterized by a dense interstitial flbrosis in which the collagen fibers are associated with an elastoid substance.
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Collaboration technique: Mmes C. Nivard, G. Pousse, Mr. A. Guidez.
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Pluot, M., Hopfner, C., Adnet, J.J. et al. Aspect ultrastructural des lesions induites au niveau du poumon de souris par le N-nitroso-N-methylurethane. Z. Krebsforsch. 77, 279–291 (1972). https://doi.org/10.1007/BF00283971
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DOI: https://doi.org/10.1007/BF00283971