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Regional localization and molecular characterization of a DNA sequence on the long arm of chromosome 22

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Summary

A human genomic DNA fragment, p22hom13 (D22S16), was isolated from a chromosome 22-specific library. After elimination of repetitive sequences, a single copy BamHI-EcoRI fragment was subcloned into pTZ18. By using mouse/human somatic cell hybrids and in situ hybridization, the new DNA probe was mapped to chromosome 22q13-qter. Its application in the analysis of the distal part of chromosome 22 and its diagnostic use in translocations are discussed.

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Authors and Affiliations

  1. Institut für Humangenetik, Universitätsklinik, D-6650, Homburg/Saar, Federal Republic of Germany

    Elisabeth Göttert, Reinhold Metzdorf, Uwe Färber & Nikolaus Blin

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  1. Elisabeth Göttert
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  2. Reinhold Metzdorf
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  3. Uwe Färber
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  4. Nikolaus Blin
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Göttert, E., Metzdorf, R., Färber, U. et al. Regional localization and molecular characterization of a DNA sequence on the long arm of chromosome 22. Hum Genet 81, 385–387 (1989). https://doi.org/10.1007/BF00283698

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  • DOI: https://doi.org/10.1007/BF00283698

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