, Volume 26, Issue 4, pp 297–299 | Cite as

Dietary protein: a trigger of insulin-dependent diabetes in the BB rat?

  • R. B. Elliott
  • J. M. Martin


Animals from a colony of spontaneously diabetic insulin-dependent BB rats were fed from weaning with semisynthetic diets in which natural proteins were replaced by l-amino acids with or without the addition of either milk or wheat proteins. The normal 50% incidence of diabetes in the colony was reduced to 15% in rats fed the basic semi-synthetic diet, while it was 35% and 52% when supplemented with gluten or milk, respectively. Thus, dietary factors might precipitate the expression of the disease.

Key words

Rat pathogenesis insulin-dependent diabetes dietary proteins milk proteins wheat proteins 


  1. 1.
    Marliss EB, Sima AAF, Nakhooda AF (1981) Spontaneous diabetes in the BB-Wistar rat. In: Martin JM, Ehrlich RM, Holland FJ (eds) Etiology and pathogenesis of insulin-dependent diabetes mellitus. Raven Press, New York, pp 251–274Google Scholar
  2. 2.
    Rogers QR, Harper AE (1965) Amino acids diets and maximal growth in the rat. J Nutrition 87: 267–273.Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • R. B. Elliott
    • 1
  • J. M. Martin
    • 1
  1. 1.Research InstituteThe Hospital for Sick ChildrenTorontoCanada

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