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Induction of chromosomal breakage in cultured human leucocytes by luteoskyrin

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Summary

Luteoskyrin, a Polyhydroxy-Bis-Dihydroanthrachinon isolated from Penicillium islandicum Sopp, is known to have strong cytotoxic effects. In long-term cultures of Ehrilich-Ascites-Tumour cells it causes the formation of very long abnormal chromosomes (Schachtschabel). Experiments with short-term cultures of human leucocytes are reported on which have shown Luteoskyrin to induce chromosomal breaks and interchromosomal bridges.

Zusammenfassung

Das Polyhydroxy-Bis-Dihydroanthrachinon Luteoskyrin, ein Stoffwechselprodukt des Schimmelpilzes Penicillium islandicum Sopp, hat eine starke cytotoxische Wirkung. In Langzeitkulturen von Ehrlich-Ascites-Tumorzellen verursacht es die Bildung von abnormal langen Chromosomen (Schachtschabel). Es wird über Versuche mit Kurzzeitkulturen von menschlichen Leukocyten berichtet, in denen durch Luteoskyrin Chromosomenbrüche und interchromosomale Brücken entstehen.

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Authors and Affiliations

  1. Department of Human Genetics, University of Marburg a. d. L., Marburg, Germany

    J. Keutel & H. Möckel

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  1. J. Keutel
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  2. H. Möckel
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Supported by a grant from Deutsche Forschungsgemeinschaft (Ke 128/1).

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Keutel, J., Möckel, H. Induction of chromosomal breakage in cultured human leucocytes by luteoskyrin. Hum Genet 7, 344–348 (1969). https://doi.org/10.1007/BF00283556

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  • DOI: https://doi.org/10.1007/BF00283556

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