Summary
This study investigates statistically, with computer assistance, the “square distances” between chromosome centromeres in homologous pairs or groups after circularizing transformation. By the method described here, it is possible to eleminate all subjective measurments and just use the coordinates x i and y i of the centromeres. The values obtained for homologous chromosomes are shown to be specific but not always small. Low “square distance” values occur in greater number for the chromosomes that are most frequently involved in aneuploïdies. This is true for acrocentric chromosomes which, moreover, tend to lie close together significantly more often in female than in male mitoses; it is also true for group 17–18 especially in males, and of XX in female mitoses. Furthermore, we find significantly low “square distances” in chromosome pair 1.
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References
Barton, D., F. N. David, and M. Merrington: The relative positions of the chromosomes in the human cell in mitosis. Ann. hum. Genet. 29, 139–146 (1965).
Defrise-Gussenhoven, E.: Generalized distance in genetic studies. Acta genet. (Basel) 17, 275–288 (1967).
Ferguson-Smith, M. A., and S. D. Handmaker: Observations on the satellited human chromosomes. Lancet 1961 I, 638–640.
Galperin, H.: Etude de la distribution générale des 46 chromosomes dans les cellules humaines en métaphase. Humangenetik 6, 118–130 (1968a)
—: Comparative study of Association of Acrocentric Chromosomes in Men an Women Mitoses. Cytogenetics 7, 447–454 (1968b).
Harnden, D. S.: The Chromosomes. Recent Advances in Human Genetics (1961). Ed. L. S. Penrose, p. 32. Boston: Little Brown, London: Churchill.
—: The London Conference on the normal karyotype. Cytogenetics 2, 264–268 (1963).
Kowarzyk, H., H. Steinhaus, and S. Szymaniec: Arrangement of chromosomes in human cells. III Distribution of centromeres and orientation of chromosomes in metaphases. Bull. Acad. pol. Sci. Cl. 2 14, 541–544 (1966).
Miller, O. J., W. R. Breg, B. B. Mukerjee, A. van N. Gamble, and A. C. Christakos: Non-random distribution of chromosomes in metaphase figure from cultured human leukocytes. II. The péripheral location of chromosomes 13, 17–18 and 21. Cytogenetics 2, 152–167 (1963).
—, B. B. Mukerjee, W. R. Breg, and A. van N. Gamble: Non-random distribution of chromosomes in metaphase figure from cultured human leukocytes. The peripheral location of the Y chromosome. Cytogenetics 2, 1–14 (1963).
Moorhead, P. S., P. C. Nowel, W. J. Mellman, D. M. Battips, and D. A. Hungerford: Chromosome preparations of leukocytes cultured from human peripheral blood. Exp. Cell. Res. 20, 613–616 (1960).
Ohno, S., J. M. Trujillo, W. D. Kaplan, and R. Kinosita: Nucleolus-organisers in the causation of chromosomal anomalies in Man. Lancet 1961 II, 123–125.
Schneiderman, L. J., and C. A. B. Smith: Non-random distribution of certain homologous pairs of normal human chromosomes in metaphase. Nature (Lond.) 195, 1229–1230 (1962).
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Galperin, H. Relative positions of homologous chromosomes or groups in male and female metaphase figures. Hum Genet 7, 265–274 (1969). https://doi.org/10.1007/BF00283549
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DOI: https://doi.org/10.1007/BF00283549