Abstract
The distribution of DNase I hypersensitive sites upstream of the chicken α-globin gene cluster was studied. A group of hypersensitive sites with a complex pattern of tissue specificity, including erythroid-specific elements, was found at a distance of 11.5–14.5 kb upstream of the π gene, the first gene in the cluster. The observations indicate that this area, located upstream of the block of AT-rich sequences and MAR sites (at −8 kb) and upstream of the site of permanent DNA attachment to the nuclear matrix (−3 kb), still belongs to the domain of the α-globin genes.
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Communicated by G.P. Georgiev
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Razin, S.V., De Moura Gallo, C.V. & Scherrer, K. Characterization of the chromatin structure in the upstream region of the chicken alpha-globin gene domain. Molec. Gen. Genet. 242, 649–652 (1994). https://doi.org/10.1007/BF00283418
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DOI: https://doi.org/10.1007/BF00283418