Summary
Fluorescent chromosome study of metastatic tumor cells (bone marrow and spinal fluid) of retinoblastoma in a 2-year-old boy revealed highly abnormal findings. The majority of the cells examined at both sites were hyperdiploid, containing 48 or 47 chromosomes. At least 6 distinct markers were found in these cells. One of the markers has a striking resemblence to the m2 marker of retinoblastoma cells described by Mark (1970). No D group abnormalities were observed in the metastatic tumor cells or in the blood of the patient.
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This work was supported in part by the United States Public Health Service Grant No. CA 10175.
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Inoue, S., Ravindranath, Y., Ottenbreit, M.J. et al. Chromosomal analysis of metastatic retinoblastoma cells. Hum Genet 25, 111–118 (1974). https://doi.org/10.1007/BF00283311
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DOI: https://doi.org/10.1007/BF00283311