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An analytical correction for peak broadening in gel permeation chromatography with a molecular weight detector

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Summary

In this paper we present a general expression describing the peak broadening effect on molecular weight averages measured during the elution of a polymer in GPC. This expression is valid for nonlinear column calibration and nonuniform Gaussian spreading across the chromatogram. Comparison is made with analytical relationships derived by Yau, Marais, Hamielec and Netopilik. The methodology developed as an extension of the Pierce and Armonas method is applied to a model system and to elution data of dextrans.

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Authors and Affiliations

  1. Department of Physical and Macromolecular Chemistry, Gorlaeus Laboratories, Leiden University, P.O.Box 9502, NL-2300, RA Leiden, The Netherlands

    G. Eggink, J. A. P. P. van Dijk & J. A. M. Smit

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  1. G. Eggink
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  2. J. A. P. P. van Dijk
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  3. J. A. M. Smit
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Eggink, G., van Dijk, J.A.P.P. & Smit, J.A.M. An analytical correction for peak broadening in gel permeation chromatography with a molecular weight detector. Polymer Bulletin 17, 531–538 (1987). https://doi.org/10.1007/BF00283089

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  • DOI: https://doi.org/10.1007/BF00283089

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