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The effects of xylitol on the secretion of insulin and gastric inhibitory polypeptide in man and rats


Xylitol given by gavage to unadapted rats produced profound diarrhoea and no rise in plasma gastric inhibitory polypeptide (GIP) concentration. In xylitol adapted rats it did not cause diarrhoea but still had no effect upon GIP release in contrast to glucose, which did. In healthy human subjects xylitol taken by mouth in solution as a single 30 g dose produced only a minimal rise in blood glucose and no rise in plasma GIP or insulin concentration. Glucose in similar doses, on the other hand, caused a large rise in all three.


  1. 1.

    Morgan LM, Goulder TJ, Tsiolakis D, Marks V, Alberti KOMM (1979) The effect of unabsorbable carbohydrate on gut hormones. Diabetologia 17: 85–89

    Google Scholar 

  2. 2.

    Jenkins DJA, Leeds AR, Gassuyl MA, Crochet B, Alberti KGMM (1977) Decrease in post-prandial glucose concentrations by guar and pectin. Ann Intern Med 86:20–23

    Google Scholar 

  3. 3.

    Förster H (1978) Tolerance in the human. Adults and children. In: Counsell JN (ed) Xylitol. Applied Science Publishers, London, pp 43–66

    Google Scholar 

  4. 4.

    Bässler KH (1969) Absorption of xylitol. In: Horecker BL, Lang K, Takagi Y (eds) Pentoses and Pentitols. Springer Verlag, Berlin pp 190–195

    Google Scholar 

  5. 5.

    Morgan LM, Morris BA, Marks V (1978) Radioimmunoassay of gastric inhibitory polypeptide. Ann Clin Biochem 15:172–177

    Google Scholar 

  6. 6.

    Soeldner JS, Stone D (1965) Critical variables in the radioimmunoassay of serum insulin using a double antibody technic. Diabetes 14:771–779

    Google Scholar 

  7. 7.

    Morgan LM (1979) Immunoassayable gastric inhibitory polypeptide: Investigations into its role in carbohydrate metabolism. Ann Clin Biochem 16:6–14

    Google Scholar 

  8. 8.

    Sykes S, Morgan LM, English J, Marks V (1980) Evidence for preferential stimulation of gastric inhibitory polypeptide secretion in the rat by actively transported carbohydrates and their analogues. J Endocrinol 85:201–207

    Google Scholar 

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Salminen, S., Salminen, E. & Marks, V. The effects of xylitol on the secretion of insulin and gastric inhibitory polypeptide in man and rats. Diabetologia 22, 480–482 (1982).

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Key words

  • Xylitol
  • GIF
  • insulin
  • diarrhoea
  • rat
  • man