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Maternal modulation of the inheritable meiosis I error Dipl I in mouse oocytes is associated with the type of mitochondrial DNA

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Summary

The ovulation of diploid oocytes, abnormally arrested at or during the first meiotic division, is an inheritable trait (Dipl I) in mice and modulated by a maternally transmitted factor. By repeated backcrossing, mouse strains with identical nuclear encoded genes and differing only in their mitochondrial genomes can be created. NMB mice represent such a strain having acquired the nuclear genome of C57BL/6J but still possessing mitochondria and therewith mitochondrial DNA (mtDNA) of NMRI/Bom, their female progenitor. The strains NMB and C57BL/6J were used to characterize a new mitochondrial trait, namely the ability to modulate the expression of the inheritable meiosis I error Dipl I in oocytes. We show that an increased rate of ovulated diploid oocytes is associated with the mtDNA type of C57BL/6J. These results corroborate the assumption that mitochondria do play an important role in meiosis of mammalian oocytes and hence seem to be involved also in the orderly segregation of chromosomes.

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References

  • Baker BS, Carpenter ATC, Esposito MS, Esposito RE, Sandler L (1976) The genetic control of meiosis. Annu Rev Genet 10:53–134

    Google Scholar 

  • Bartels I, Jenderny J, Hansmann I (1984) Control of meiosis by somatic cells in mice: inheritance of the meiosis I error “diploidy” and nondisjunction in sensitive NMRI/Han oocytes ovulated from chimaeras. Cell Differ 15:189–194

    Google Scholar 

  • Beermann F, Hansmann I (1986) Follicular maturation, luteinization and first meiotic division in oocytes after inhibiting mitochondrial function in mice with chloramphenicol. Mutat Res 160:47–54

    Google Scholar 

  • Beermann F, Bartels I, Franke U, Hansmann I (1987a) Chromosome segregation at meiosis I in female T(2;4)1Gö/+ mice: no evidence for a decreased crossover frequency with maternal age. Chromosoma 95:1–7

    Google Scholar 

  • Beermann F, Jenderny J, Hummler E, Hansmann I (1987b) Inheritance of a meiosis I error expressed in mouse oocytes and modulated by a maternal factor. Genet Res 49:239–243

    Google Scholar 

  • Bibb MJ, Van Etten RA, Wright CT, Walberg MW, Clayton DA (1981) Sequence and gene organization of mouse mitochondrial DNA. Cell 26:167–180

    Google Scholar 

  • Blerkom J van, Runner MN (1984) Mitochondrial reorganization during resumption of arrested meiosis in the mouse oocyte. Am J Anat 171:335–355

    Google Scholar 

  • Bogenhagen D, Clayton DA (1974) The number of mitochondrial deoxyribonucleic acid genomes in mouse L and human HeLa cells. J Biol Chem 249:7991–7995

    Google Scholar 

  • Ferris SD, Ritte U, Fischer Lindahl K, Prager EM, Wilson AC (1983) Unusual type of mitochondrial DNA in mice lacking a maternally transmitted antigen. Nucleic Acids Res 11:2917–2926

    Google Scholar 

  • Fischer Lindahl K, hausmann B (1983) Cytoplasmic inheritance of a cell surface antigen in the mouse. Genetics 103:483–494

    Google Scholar 

  • Hansmann I, Bartels I, Beermann F, Caspari D, Franke U, Hummler E, Theuring F (1985) Mechanisms of nondisjunction: facts and perspectives. In: Dellarco VL, Voytek PE, Hollaender A (eds) Aneuploidy: etiology and mechanisms. Plenum Press, New York, pp 417–432

    Google Scholar 

  • Hyttel P, Callesen H, Greve T (1986) Ultrastructural features of preovulatory oocyte maturation in superovulated cattle. J Reprod Fertil 76:645–656

    Google Scholar 

  • Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

    Google Scholar 

  • Privalle CT, Crivello JF, Jefcoate CR (1983) Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland. Proc Natl Acad Sci USA 80: 702–706

    Google Scholar 

  • Spinner NB, King MC (1986) Polymorphisms of mitochondrially encoded proteins. Am J Hum Genet 38:159–169

    Google Scholar 

  • Yonekawa H, Moriwake K, Gotoh O, Miyashita N, Migita S, Bonhomme F, Hjorth JP, Petras ML, Tagashira Y (1982) Origins of laboratory mice deduced from restriction patterns of mitochondrial DNA. Differentiation 22:222–226

    Google Scholar 

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Authors and Affiliations

  1. Institut für Humangenetik der Universität, Gosslerstrasse 12d, D-3400, Göttingen, Federal Republic of Germany

    Friedrich Beermann, Edith Hummler, Ulrich Franke & Ingo Hansmann

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  1. Friedrich Beermann
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  2. Edith Hummler
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  3. Ulrich Franke
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  4. Ingo Hansmann
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Beermann, F., Hummler, E., Franke, U. et al. Maternal modulation of the inheritable meiosis I error Dipl I in mouse oocytes is associated with the type of mitochondrial DNA. Hum Genet 79, 338–340 (1988). https://doi.org/10.1007/BF00282172

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  • DOI: https://doi.org/10.1007/BF00282172

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