Summary
Multiple abnormal karyotypes representing apparently unrelated clones were observed in initial bone marrow samples from two polycythemia vera patients. Serial sampling demonstrated a selective advantage in proliferation of one clone over the others. The predominance of the single clone was associated with progression of the disease.
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Testa, J.R., Kanofsky, J.R., Rowley, J.D. et al. Multiple cytogenetically abnormal clones in two polycythemia vera patients. Hum Genet 57, 165–168 (1981). https://doi.org/10.1007/BF00282014
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DOI: https://doi.org/10.1007/BF00282014