Summary
Two cases of newborn male infants afflicted with trisomy 18 and with signs of arthrogryposis multiplex congenita (AMC) are described. Anomalies occurring in most cases of trisomy 18 such as polyhydramnios, reduced foetal activity, and skeletal muscle hypoplasia decrease articular movements and, thus, might cause AMC. Since AMC is rarely associated with trisomy 18, chromosomal aberration is not the only factor involved in these cases.
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References
Beitzke A (1972) Vier Fälle von Trisomie E. Diagnose und Differential-diagnose. Paediatr Paedol 7:183–189
Drachman DB, Weiner LP, Price DL, Chase J (1976) Experimental arthrogryposis caused by viral myopathy. Arch Neurol 33:362–367
Friedlander HL, Westin GW, Wood WL Jr (1968) Arthrogryposis multiplex congenita. A review of forty-five cases. J Bone Jt Surg [Am] 50:89–112
Lebenthal EB, Shochet B, Adam A, Seelenfreund M, Fried A, Najenson T, Sandbank U, Matoth Y (1970) Arthrogryposis multiplex congenita. Twenty-three cases in an Arab kindred. Pediatrics 46: 891–899
Murray PDF, Drachman DB (1969) The role of movement in the development of joints and related structures: the head and neck in the chick embryo. J Embryol Exp Morphol 22:349–371
Pfeiffer RA, Huther W (1963) Trisomie des Chromosoms Nr. 18 unter dem Bild einer Arthrogryposis multiplex congenita. Med Klin 58: 1110–1114
Wynne-Davies R, Lloyd-Roberts GC (1976) Arthrogryposis multiplex congenita. Search for prenatal factors in 66 sporadic cases. Arch Dis Child 51:618–623
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Lambert, J.C., Ferrari, M., Donzeau, M. et al. Arthrogryposis-like signs in trisomy 18. Hum Genet 57, 145–147 (1981). https://doi.org/10.1007/BF00282011
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DOI: https://doi.org/10.1007/BF00282011