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The pattern of radiation-induced transmissible aberrations in a human cell culture

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Summary

The G-band pattern in 445 metaphases obtained seven weeks after irradiation (600 rad gamma-ray) was analysed. Approximately 37% of these cells had one or more structural aberrations. The majority of the aberrant events was reciprocal translocation followed by inversion and deletion in the proportion of 9:1:1 respectively. Statistical analyses (Chi-square tests) on the distribution of breakpoints among chromosomes showed an excess number of breaks in chromosomes 1,7,and 12. Chromosomes 1 and 12 were particularly involved in cells carrying multiple aberrations while chromosome 7 was preferentially involved in deletion. Within chromosomes a significantly large number of breaks were located in(a) the light bands and (b) the terminal segments. The significance of these findings is discussed.

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Author notes

  1. C. L. Y. Lee

    Present address: Department of Microbiology, Sir Charles Tupper Building, Dalhousie University, B3H 4H7, Halifax, N.S., Canada

Authors and Affiliations

  1. Radiation Biology Laboratory, Department of Biology, Life Science Center, Dalhousie University, B3H 4J1, Halifax, N.S., Canada

    C. L. Y. Lee & O. P. Kamra

Authors
  1. C. L. Y. Lee
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  2. O. P. Kamra
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Lee, C.L.Y., Kamra, O.P. The pattern of radiation-induced transmissible aberrations in a human cell culture. Hum Genet 57, 380–384 (1981). https://doi.org/10.1007/BF00281689

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  • DOI: https://doi.org/10.1007/BF00281689

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