Skip to main content
Log in

Verapamil and drug metabolism by the cytochrome P450 isoform CYP1A2

  • Letter To The Editors
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Nielsen-Kudsk JE, Buhl JS, Johannessen AC (1990) Verapamil-induced inhibition of theophylline in healthy humans. Pharmacol Toxicol 66: 101–103

    Google Scholar 

  2. Robson RA, Miners JO, Matthews AP, Stupans I, Meller D, McManus M, Birkett DJ (1988) Characterisation of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studies. Biochem Pharmacol 37: 1651–1659

    Google Scholar 

  3. Butler MA, Iwasaki M, Guengerich FP, Kadlubar FK (1989) Human cytochrome P450PA (P-450IA2), the phenacetin O-deethylase, is primary responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci USA 86: 7696–7700

    Google Scholar 

  4. Fuhr U, Wolff T, Harder S, Schymanski P, Staib AH (1990) Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes. Drug Metabol Dispos 18: 1005–1010

    Google Scholar 

  5. Sesardic D, Boobis AR, Murray BP, Murray S, Segura J, de la Torre R, Davies DS (1990) Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man. Br J Clin Pharmacol 29: 651–663

    Google Scholar 

  6. Kroemer HK, Beaune P, Henderson CJ, Wolf CR, Heidemann H (1991) Identification of cytochrome P-450 isozymes involved in the metabolism of verapamil. Arch Pharmacol 343 [Suppl]: R124

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fuhr, U., Woodcock, B.G. & Siewert, M. Verapamil and drug metabolism by the cytochrome P450 isoform CYP1A2. Eur J Clin Pharmacol 42, 463–464 (1992). https://doi.org/10.1007/BF00280138

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00280138

Key words

Navigation